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Home > "G" Clinical Trials Conditions > Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions  Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
For Condition: Arthritis, Psoriatic,Autoimmune Diseases,Joint Diseases,Osteoarthritis,Rheumatoid Arthritis
Status: Completed
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ,
Synopsis: This protocol will examine blood, synovial fluid and synovial tissue from patients with rheumatoid arthritis and other chronic inflammatory joint diseases to study genetic and immunologic factors involved in the cause, development and progression of these conditions. Synovial fluid is the lubricating fluid in joints. The synovial membrane is a delicate tissue lining the inner surface of joints, which, in arthritic conditions, thickens and becomes infiltrated with various types of cells. Patients with rheumatoid arthritis and certain patients with other forms of arthritis may be eligible for this study. Those enrolled will be followed periodically for follow-up and disease evaluation. They may undergo the following procedures: 1. Synovial fluid aspiration, when medically indicated (for example, for joint swelling and inflammation). For this procedure, an area of skin around the joint is numbed with an anesthetic, and a needle is inserted into the joint to withdraw a small fluid sample. 2. Periodic blood sampling, not to exceed 450 milliliters (15 ounces) during any 6-week period, for genetic studies of rheumatoid arthritis. The samples are usually taken at the same times that synovial fluid is withdrawn. 3. Synovial tissues, collected by needle biopsy or during surgical procedures for arthroscopy (examination of the interior of the joint and repair of the joint) or total joint replacement. For the needle biopsy, the skin over the biopsy site is washed and anesthetized. A needle is inserted and fluid is aspirated. The biopsy needle is then inserted through the outer needle and a tissue sample is suctioned. Patients who qualify for other research studies may be invited to participate.
Details: Blood, synovial fluids and/or synovial tissues will be obtained from patients with rheumatoid arthritis and related chronic inflammatory arthritides. The synovial tissues will be obtained by one of the following methods: a) needle biopsy, or b) at the time of a total joint replacement or a therapeutic arthroscopic procedure. These materials will be utilized for laboratory studies of etiopathogenetic mechanisms of rheumatoid arthritis and related autoimmune joint diseases.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients with rheumatoid arthritis, particularly new onset disease, but certain patients with other forms of arthritis will also be included. Significantly swollen or tender knee or significantly swollen shoulders, elbows, wrists, ankles, olecranon bursa or even smaller joints. Synovial tissue specimens will not be obtained from patients when any of the following conditions are present: abnormal bleeding or clotting tests, platelet count less than 100,000, or sepsis.
Total Enrollment: 9999
Location and Contact Information:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 920065; 92-AR-0065
Study Start Date: December 31, 1991
Record last reviewed: December 17, 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001291
Other Arthritis, Psoriatic Studies:
1. Treatment of Childhood Onset Psychiatric Disorders with Intravenous Immunoglobulin (IVIg)
2. Phase II Study of High-Dose Cyclophosphamide in Patients With Severe Autoimmune Hematologic Disease
3. Study of Silicone-Associated Connective Tissue Diseases
4. Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
5. Treatment of Multiple Sclerosis with Copaxone and Albuterol
Related Studies:
Other Arthritis, Psoriatic Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
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