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Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection Clinical research trials and Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection. Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection clinical trial. Human subjects often get the best healthcare available for their Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.
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Home > "E" Clinical Trials Conditions > Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection  Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection
Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection
For Condition: Blastomycosis
Status: Recruiting
Sponsor(s): National Cancer Institute (NCI) ,
Synopsis: Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Blastomycosis dermatitidis. To test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor IIa and IIb, Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of Blastomycosis dermatitidis infection. With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive Blastomycosis dermatitidis infection.
Details: Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Blastomyces Dermatitidis. To test this hypothesis, we propose to analyze the allelic frequencies of 14 different genes (mannose binding lectin, Fc-gamma receptor Iia and IIb, Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of Blastomyces Dermatitidis infection. With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive Blastomyces Dermatitidis infection.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Patients in the database have been confirmed with a diagnosis of Blastomycosis dermatitides infection by a combination of isolation of the yeast form in a diagnostic microbiology laboratory and/or an elevated cryptococcal antigen titer (which is commercially available). Only patients diagnosed and treated in the United States and Canada will be included in this analysis. Only patients who are not co-infected with HIV will be included in the study. Patient samples will be collected and clinical data will be evaluated only after signed consent has been obtained.
Total Enrollment: 125
Location and Contact Information:
National Cancer Institute (NCI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Clinical Support Center/NCI 1-888-624-1937
Additional Information:
Study ID Numbers: 980138; 98-C-0138
Study Start Date: July 29, 1998
Record last reviewed: July 1, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001702
Other Blastomycosis Studies:
1. A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis
2. Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection
3. Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis
4. Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis
Related Studies:
Other Blastomycosis Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection
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