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Home > "E" Clinical Trials Conditions > Evaluation of Healthy Volunteer Marrow Donors Participating in the National Marrow Donor Program (NMDP)  Evaluation of Healthy Volunteer Marrow Donors Participating in the National Marrow Donor Program (NMDP)
Evaluation of Healthy Volunteer Marrow Donors Participating in the National Marrow Donor Program (NMDP)
For Condition: Healthy
Status: Recruiting
Sponsor(s): Warren G Magnuson Clinical Center (CC) ,
Synopsis: Individuals interested in becoming prospective bone marrow donors and joining the Registry of the National Marrow Donor Program (NMDP) should do so by calling 301-496-0572, the phone number of the NIH Marrow Donor Center. An appointment will be made to have a health history taken and to have blood drawn for tissue (HLA) typing. The current protocol only involves donors already registered with the NMDP, who have been identified as "perfect matches" for an unrelated patient requiring a bone marrow transplant, and who require expedited medical evaluation prior to marrow collection.
Details: The National Marrow Donor Program (NMDP) was established in 1987 in order to (1) create a registry of volunteer, prospectively tissue-typed, unrelated bone marrow donors, (2) facilitate the performance of matched unrelated donor marrow transplants through a coordinated circuit of Donor Centers, Collection Centers and Transplant Centers throughout the United States, and (3) evaluate the outcome of such transplants and identify future areas of research in the field of unrelated donor marrow transplants. The NIH Marrow Donor Center, a participant in the NMDP, is one of the largest hospital-based Donor Centers in the nation, with 55,200 active donors on its registry. 298 NIH unrelated donors to date have undergone marrow or blood stem cell harvest for an NMDP recipient, and the current rate of such harvests is three per month. Once an HLA-matched donor in the NIH Donor Center registry is identified through the NMDP computer network, the donor must undergo a medical evaluation to determine suitability for marrow harvest. This evaluation consists of a medical history, a physical examination, routine blood work, EKG, chest x-ray, and urinalysis, and generally takes 4 to 6 weeks. The evaluation is usually performed by a "third party" non-NIH physician, with the costs reimbursed by the NMDP. Occasionally, an expedited evaluation of an unrelated donor must be performed, due to the urgency of the need for a transplant in the recipient, and there is insufficient time to accomplish this work-up using the routine "third-party" physician's office mechanism. This protocol shall provide a means by which prospective NIH unrelated marrow donors participating in the NMDP program can undergo an expedited medical evaluation to determine suitability for marrow donation. It is expected that not more than 5 to 10 donors per year shall require such expedited evaluation.
Eligibility:
Study Type: Observational, Screening
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Age 18-60. Must meet same criteria as that of a volunteer blood donor. EXCLUSION CRITERIA: History of hepatitis. History of intravenous use of illicit drugs. History of activities that increase the risk of exposure to HIV or hepatitis viruses. Inability to tolerate general anesthesia. Obesity. Hypertension. Asthma. Diabetic patients will be excluded. Pregnant patients will be excluded.
Total Enrollment: 100
Location and Contact Information:
Warren G. Magnuson Clinical Center (CC) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 950123; 95-CC-0123
Study Start Date: March 14, 1995
Record last reviewed: February 11, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001451
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