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Evaluation of Echinacea for the Common Cold



Evaluation of Echinacea for the Common Cold

For Condition: Common Cold
Status: No longer recruiting
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: The purpose of this study is to determine whether three Echinacea preparations with different chemical compositions are effective for prevention or treatment of the common cold.
Details: Echinacea is a widely used herbal remedy for the common cold. Previous clinical trials designed to assess the efficacy of Echinacea for prevention or treatment of the common cold have produced inconsistent results. A variety of different Echinacea products have been used in these clinical trials. Recent studies indicate that different Echinacea preparations have dramatically different phytochemical profiles. The available clinical trial data provide no information about the potential role of the different constituents of Echinacea in common cold prevention or treatment. Our hypothesis is that the variation in reported clinical effectiveness may be due to differences in the phytochemical profile of the Echinacea preparations used. This study will address the following specific aims: 1) Evaluate the effectiveness of chemically defined extracts of E. angustifolia root which contain alkamides, echinacoside or polysaccharidelglycoprotein for common cold prevention or treatment; 2) Assess the correlation between specific Echinacea metabolites in serum and nasal secretions and efficacy for prevention and treatment of colds; and 3) Determine the effect of different Echinacea preparations on the host response to rhinovirus infection.
Eligibility:
Study Type:  Interventional, Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: /
Genders: 
Protocol Entry Criteria: 
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
J.Gangemi,  ,  Clemson University

University of Virginia, Charlottesville
Charlottesville,  Virginia,  22904
United States
 


Additional Information:
Study ID Numbers:  1 R01 AT01146-01; 
Study Start Date: September 2001
Record last reviewed: May 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00032500

Other Common Cold Studies:
1. Evaluation of Echinacea for the Common Cold

2. A Randomized Controlled Trial of Echinacea in Children

3. Echinacea Versus Placebo Effect in Common Cold

Related Studies:

Other Common Cold Clinical Trials
Other Virginia Clinical Trials
Other Charlottesville Clinical Trials

Evaluation of Echinacea for the Common Cold
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