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Home > "E" Clinical Trials Conditions > Evaluating Muscle Function After Ankle Surgery  Evaluating Muscle Function After Ankle Surgery
Evaluating Muscle Function After Ankle Surgery
For Condition: Fractures,Muscle Atrophy,Muscle Weakness
Status: Completed
Sponsor(s): National Institute of Child Health and Human Development (NICHD) ,
Synopsis: Patients who are forced to rest or reduce activity as a result of illness, injury, or surgery often experience resulting muscle weakness. This study will evaluate muscle features and muscle strength in patients who are recovering from surgery for broken ankles. The goal of this study is to improve the recovery of muscle function and overall ability after prolonged periods of ankle inactivity due to surgery.
Details: Many physiological conditions are associated with muscle weakness and can affect movement. This study will investigate which metabolic and morphological features of skeletal muscle are uniquely altered during the course of rehabilitation and how they affect muscle function and performance in daily ambulatory activities. This study will also examine how well the commonly used assessment measures reflect actual muscle capacity. Finally, because there is evidence that activity does not affect all fiber types uniformly, fiber-type specific metabolic and morphological measures will be performed. Participants in this study will have had an ankle injury that has been treated surgically (Open Reduction Internal Fixation, or ORIF) followed by 5 to 10 weeks of cast immobilization. Following initial baseline measurements made after 1 week of reambulation, participants are enrolled in a 10-week rehabilitation program that focuses on restoration of both muscle strength and endurance. Assessments are made at Weeks 5 and 10 and include 31P-Magnetic Resonance Spectroscopy (MRS), Magnetic Resonance Imaging (MRI), muscle biopsy, and muscle function and functional performance tests. 31P-measurements monitor changes in the in vivo metabolic characteristics of skeletal muscle. 3D-MRI procedures will be used to quantify the maximal muscle cross-sectional area and total muscle volume. Muscle endurance and strength will be measured using an isokinetic dynamometer. Functional performance tests consist of self-selected walking pace, power for ascending and descending stairs, and toe raises while standing on one foot. Nine participants (six patients and three control volunteers) will be studied each year. Control volunteers are submitted to the same measurements at similar time intervals in order to assess variability over time.
Eligibility:
Study Type: Observational, Natural History, Longitudinal, Convenience Sample, Prospective Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - 5 to 10 weeks of cast immobilization following surgery (ORIF) for mallerolar fracture Exclusion Criteria: - Pregnant or breastfeeding - Severe claustrophobia - MRI incompatible metal implants (e.g., pacemaker) - Diabetes or peripheral neuropathies - Bleeding disorders
Total Enrollment: 30
Location and Contact Information:
Overall Study Official:
KristaVandenborne, Principal Investigator, University of Pennsylvania, Department of Physiology
MMRRCC, University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States
Additional Information:
Study ID Numbers: R29HD33738;
Study Start Date: September 1995
Record last reviewed: March 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00060970
Other Fractures Studies:
1. Evaluating Muscle Function After Ankle Surgery
Related Studies:
Other Fractures Clinical Trials
Other Pennsylvania Clinical Trials
Other Philadelphia Clinical Trials
Evaluating Muscle Function After Ankle Surgery
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