|
Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis Clinical research trials and Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis. Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis clinical trial. Test subjects typically receive the most expert healthcare available for their Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
|
|
|
|
|
|
|
Home > "E" Clinical Trials Conditions > Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis  Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis
Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis
For Condition: Hemiparesis,Cerebrovascular Accident
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Rehabilitation Research and Development Service ,
Synopsis: Our overall goal is to develop therapeutic interventions to improve upper-limb motor function in hemiparetic persons based on an improved understanding of the mechanisms responsible for its loss and recovery. We intend to rigorously evaluate the efficacy of these interventions with clinical trials, and to study the mechanisms by which these interventions affect motor recovery. In this proposal, we will use a controlled, randomized, double blind clinical trial to study the effects of shoulder and elbow strength training in subjects in the subacute phase of recovery following stroke.
Details: Hypotheses: The specific hypotheses that we will test in this proposal all refer to persons with post-stroke hemiparesis in the subacute phase of recovery (completed all out-patient therapy programs, but still less than 6 months post-CVA). 1. a) Standard functional rehabilitation combined with strength training in the form of high-intensity resistance exercise results in greater gains in elbow and shoulder strength than standard functional rehabilitation alone. b) This increased strength is not accompanied by increased hypertonia. c) This increased strength is not accompanied by significant muscular hypertrophy. 2. Standard functional rehabilitation combined with strength training results in greater improvements in motor function than functional rehabilitation alone. 3. Strength training results in improved control of elbow trajectory tracking movements and shoulder-elbow reaching movements. Specific Objectives 1. To perform a controlled, randomized, double-blind clinical trial to test the effects of high-intensity resistance exercise at the shoulder and elbow. Two interventions will be compared: standard functional rehabilitation (SFR), and standard functional rehabilitation combined with high-intensity resistance exercise (strength training) (SFR+STR). We will study persons with post-stroke hemiparesis in the subacute phase of recovery, i.e. having completed all outpatient therapy programs, but still less than 6 months post-CVA. Outcome measures will include strength (maximal voluntary isovelocity joint torque), hypertonia (onset threshold of the stretch reflex, Modified Ashworth Scale), standard clinical assessment of activities of daily living (Barthel Index, Functional Independence Measure), and upper extremity motor function (Fugl-Meyer exam, Functional Test of the Hemiparetic Upper Extremity). 2. To study the neuromuscular mechanisms associated with improvements in strength and motor control that result from these interventions. Strength changes will be investigated by measuring muscle hypertrophy, hyperreflexia, and passive stiffness. Changes in control of upper extremity movements will be investigated by measuring motor performance and muscle activation patterns in trajectory tracking and reaching tasks. Our long term goal is to develop therapeutic interventions to improve upper-limb motor function in persons with post-stroke hemiparesis. Improved motor function involves not only increased strength at the shoulder and elbow, but also increased strength and dexterity at the wrist and hand. The proposed study will establish a foundation by demonstrating the positive effects of strength training in persons with hemiparesis. Then, in future studies, we can investigate the effects of specific interventions at the hand and wrist and investigate physiologic mechanisms subserving change in neuromuscular function following strength training.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Active Control, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Post stroke
Total Enrollment: 60
Location and Contact Information:
Overall Study Official:
DanielleKerkovitch, , Program Analysis and Review Section (PARS), VA Rehabilitation Research and Development Service
VAMC *Recruiting*
Palo Alto, California,
United States
Recruiting Peter Lum 650-493-5000
Additional Information:
Study ID Numbers: B2405;
Study Start Date: October 2000
Record last reviewed: May 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00037908
Other Cerebrovascular Accident Studies:
1. Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis
2. Walking Therapy In Hemiparetic Stroke Patients Using Robotic-Assisted Treadmill Training
Related Studies:
Other Cerebrovascular Accident Clinical Trials
Other California Clinical Trials
Other Palo Alto Clinical Trials
Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis
|
|
|
|
|
|
|
|
