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Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics Clinical research trials and Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics. Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics clinical trial. Test subjects typically receive the most expert healthcare available for their Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "E" Clinical Trials Conditions > Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics  Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
For Condition: Respiratory Insufficiency,Anoxemia
Status: Recruiting
Sponsor(s): INO Therapeutics ,
Synopsis: The purpose of this study is to determine the effect of nitric oxide for inhalation on the duration of mechanical ventilation in pediatric patients with AHRF.
Details: Patients will receive 5-ppm study gas (nitric oxide for inhalation or placebo) until Day 28 or extubation, whichever comes first. The following will be performed / recorded at specified times during the study: arterial blood gases, ventilator settings, methemoglobin, PRISM III score, and patient positioning. Selected centers will also be performing plasma cytokine assays, broncho-alveolar lavage fluid assays and a 6 month follow-up assesssment.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: /16 Years
Genders: Both
Protocol Entry Criteria: Inclusion criteria: - Admitted to pediatric intensive care unit and have the diagnosis of acute repiratory failure - 44 weeks post conceptional age to 16 years of age - Oxygenation Index (OI) >=12 cm H2O/mmHg (as determined by two separate measurement taken 30 minutes to 4 hours apart) - Recent chest x-ray (within 24 hours) showing at least unilateral infiltrations - Mechanically ventilated <= 7 days Exclusion criteria: - Immunocompromised - Received a bone marrow transplant - Active oncological condition - Persistent right to left intracardiac shunt - Cardiovascular surgery within the last 14 days - Status asthmaticus - Decision by primary care physician not to provide full support - Received treatment with nitric oxide for inhalation or other investigational medications within 24 hours prior to study initiation, participating in surfactant trials - Chronically ventilated - Pregnant
Total Enrollment: 350
Location and Contact Information:
The Children's Hospital *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Emily Dobyns
New York Presbyterian Hospital *Not yet recruiting*
New York City, New York, 10021
United States
Not yet recruiting H. Ushay
University of Chicago, Children's Hospital *Recruiting*
Chicago, Illinois, 60637
United States
Recruiting Michael Schrieber
Oregon Health and Science University *Recruiting*
Portland, Oregon, 97239
United States
Recruiting Dana Braner
The Medical University of South Carolina *Not yet recruiting*
Charleston, South Carolina, 29425
United States
Not yet recruiting David Habib
Vanderbilt University Medical Center *Recruiting*
Nashville, Tennessee, 37232
United States
Recruiting Neal Patel
Children's Healthcare of Atlanta at Egleston *Recruiting*
Atlanta, Georgia, 30322
United States
Recruiting James Fortenberry
Chrildren's Hospital of Orange County *Recruiting*
Orange, California, 92868
United States
Recruiting Ronald Bronicki
Additional Information:
Study ID Numbers: INOT-11;
Study Start Date: January 2002
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00041561
Other Respiratory Insufficiency Studies:
1. Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
Related Studies:
Other Respiratory Insufficiency Clinical Trials
Other Tennessee Clinical Trials
Other Nashville Clinical Trials
Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
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