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Effects of Exercise on patients with Hemiparetic Stroke



Effects of Exercise on patients with Hemiparetic Stroke

For Condition: Cardiovascular Disease,Hemiplegia,Stroke
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: This randomized trial investigates the hypothesis that regular aerobic exercise training using a task specific gait training modality will improve cardiovascular fitness, functional mobility, and reduce risk factors for recurrent cardiovascular events in chronic hemiparetic stroke patients, when compared to matched controls performing just stretching.
Details: The aims are to determine whether 6 months progressive graded treadmill training: 1) improves cardiovascular fitness levels and reduces the excessive energy demands of hemiparetic gait, as defined by oxygen consumption levels based on open circuit spirometry during peak and submaximal exercise ambulation tasks; 2) increases free living physical activity measured by portable kinematic recording devices and quantitative in vivo determination of energy expenditure using stable isotopes; and, 3) improves the cardiovascular-metabolic risk factor profile including measures of key endogenous fibrinolysis regulatory enzymes [plasma tissue plasminogen activator (t-PA) and its main circulating inhibitor (PAI-1)], fasting lipoprotein lipid profiles, blood pressure, and oral glucose tolerance and insulin responses. Measurements of body composition at baseline and after training will further determine the effects of aerobic exercise training on muscle mass and central obesity.
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Active Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 40 Years/80 Years
Genders: Both
Protocol Entry Criteria: Males or Females Ages 40 yrs to 80 yrs who are chronic hemiparetic stroke patients.
Total Enrollment: 

Location and Contact Information:

VA Maryland Health Care System *Recruiting*
Baltimore,  Maryland,  21201
United States
Recruiting Richard  Macko 410-605-7063


Additional Information:
Study ID Numbers:
  CADE-RA; 
Study Start Date: July 1997
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018421

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