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Home > "E" Clinical Trials Conditions > Effectiveness of KOS-862 in the Treatment of Lung Cancer  Effectiveness of KOS-862 in the Treatment of Lung Cancer
Effectiveness of KOS-862 in the Treatment of Lung Cancer
For Condition: Lung Cancer
Status: Recruiting
Sponsor(s): Hoffmann-La Roche , Kosan Biosciences
Synopsis: The purpose of this study is to determine whether a potential drug known as KOS-862 or “Epothilone D” has an effect as a 2nd line treatment in non-small cell lung cancer (NSCLC) for patients having failed one prior platinum-containing chemotherapy regimen.
Details: To determine the antitumor activity, based on the confirmed objective response rate, of KOS-862, administered intravenously weekly for 3 weeks every 4 weeks, in patients with non-small cell lung cancer (NSCLC) whose disease has progressed following intitial chemotherapy for advanced or metastatic disease.
Eligibility:
Study Type: Interventional,Treatment,Non-Randomized,Open Label,Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - At least 18 years of age - Measurable disease - One previous treatment of a platinum based drug such as cisplatin or carboplatin - At least 3 weeks since last surgery/radiation/chemotherapy Exclusion Criteria: - Brain metastases - Changes in the rhythm of your heart that are considered significant as determined by an ECG tracing
Total Enrollment: 85
Location and Contact Information:
Memorial Sloan-Kettering Cancer Center *Recruiting*
New York City, New York, 02115
United States
Recruiting Ester Ro 646-227-2187
Saint Francis Memorial Hospital *Recruiting*
San Francisco, California, 94109
United States
Recruiting Mark Jacobs 415-353-6863
Dana-Farber Cancer Institute *Recruiting*
Boston, Massachusetts, 02115
United States
Recruiting Joan Lucca 617-632-5403
Massachusetts General Hospital (MGH) *Recruiting*
Boston, Massachusetts, 02114
United States
Recruiting Allison Brassard 617-726-1849
Ohio State University *Recruiting*
Columbus, Ohio, 43210
United States
Recruiting Tamara Criswell 614-293-7361
University Internal Medicine Associates *Recruiting*
Cincinnati, Ohio, 45267
United States
Recruiting Brandon Kleykamp 513-584-3183
Greater Baltimore Memorical Center (GBMC) *Recruiting*
Baltimore, Maryland, 21204
United States
Recruiting Mechelle Barrick 443-849-8058
Vanderbilt University Medical Center *Recruiting*
Nashville, Tennessee, 37232-5536
United States
Recruiting Teresa Knoop 800-811-8400
Additional Information:
Study ID Numbers: KOS-201/NO17352;
Study Start Date: December 2003
Record last reviewed: May 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00080509
Other Lung Cancer Studies:
1. Gene Therapy in Treating Patients With Cancer
2. Docetaxel in Treating Patients With Solid Tumors and Abnormal Liver Function
3. Amifostine Followed by High Dose Chemotherapy in Treating Patients With Hematologic Cancer or Solid Tumors
4. Effectiveness of KOS-862 in the Treatment of Lung Cancer
5. Liposomal Lurtotecan Plus Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors
Related Studies:
Other Lung Cancer Clinical Trials
Other California Clinical Trials
Other San Francisco Clinical Trials
Effectiveness of KOS-862 in the Treatment of Lung Cancer
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