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Effect of pravastatin on endothelial dysfunction following a single high fat meal Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified health advice, travels to or treatment by using a genuine physician. We are not physicians. Always consult your dr. on Effect of pravastatin on endothelial dysfunction following a single high fat meal conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Effect of pravastatin on endothelial dysfunction following a single high fat meal Clinical research trials and Effect of pravastatin on endothelial dysfunction following a single high fat meal health trials occur in hundreds of cities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new drugs. The propose of the studies / undertakings is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector companies to locate treatments for all sorts of conditions, including Effect of pravastatin on endothelial dysfunction following a single high fat meal. Effect of pravastatin on endothelial dysfunction following a single high fat meal Clinical Trials and other clinical trials permit volunteers to acquire medical treatment choices before they are available to the masses. Some times the test subjects obtain professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Effect of pravastatin on endothelial dysfunction following a single high fat meal clinical trial. Participants oftentimes recieve the most expert healthcare available for their Effect of pravastatin on endothelial dysfunction following a single high fat meal condition. Hazards are a reality, however, and can include extra or frequent physician visits, health risks (potentially life-endangering), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "E" Clinical Trials Conditions > Effect of pravastatin on endothelial dysfunction following a single high fat meal  Effect of pravastatin on endothelial dysfunction following a single high fat meal
Effect of pravastatin on endothelial dysfunction following a single high fat meal
For Condition: Heart Diseases
Status: No longer recruiting
Sponsor(s): National Center for Research Resources (NCRR) ,
Synopsis: There is significant evidence that HMG-CoA reductase inhibitors, a commonly used class of cholesterol lowering medications, reduce the risk of death from coronary disease. Although these medicines lower cholesterol levels, other studies suggest that they have an additional effect on improving blood vessel functioning. It has also been shown that consumption of a fatty meal temporarily alters blood vessel functioning, causing endothelial dysfunction. This study will examine if pravastatin, an HMG-CoA reductase inhibitor, improves blood vessel functioning after a fatty meal. We plan on enrolling 32 subjects, aged 18-40 years, who are healthy with no history of diabetes, smoking, high blood pressure, or heart disease. These subjects will be randomly assigned to initially receive four days of pravastatin or an inactive substance, and then crossed over to the other group. Blood vessel functioning will be monitored by a technique called flow mediated vasoactivity, which uses ultrasound measurement of the forearm artery and its response to temporary occlusion. This primary measure of flow mediated vasoactivity will be done before and after consumption of a fatty meal. We hope to show that treatment with pravastatin prevents the blood vessel dysfunction known to occur after a high fat meal. Secondary outcomes will include measurement of endothelin-l, a mediator of blood vessel functioning, and assessment of changes in lipid profiles. If pravastatin does prevent endothelial dysfunction in this setting, it could lead to further studies about their use in more acute medical settings, including heart attacks or strokes.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control
Minimum Age/Maximum Age: 18 Years/40 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - No history of the following: hypertension, diabetes mellitus, smoking, and coronary artery disease
Total Enrollment:
Location and Contact Information:
4200 E. 9th Avenue, Box B133
Denver, Colorado, 80262
United States
Additional Information:
Study ID Numbers: NCRR-M01RR00051-1162; M01RR00051
Study Start Date:
Record last reviewed: November 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005117
Other Heart Diseases Studies:
1. Gender Response To Coronary Risk
2. Epidemiology of Symptomatic Arrhythmias
3. Increased Physical Activity in African-American Women
4. Epidemiology of Coronary Calcification in the Elderly
5. Prognostic Significance of T Wave Alternans
Related Studies:
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Effect of pravastatin on endothelial dysfunction following a single high fat meal
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