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Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass Clinical research trials and Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass. Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass clinical trial. Participants oftentimes recieve the finest healthcare available for their Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "E" Clinical Trials Conditions > Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass
Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass
For Condition: Cardio-pulmonary Bypass,Coronary Artery Bypass Graft
Status: No longer recruiting
Sponsor(s): Alexion Pharmaceuticals ,
Synopsis: During a heart bypass procedure, a substance called "complement" is released by the body. This complement causes inflammation, which can lead to side effects such as chest pain, heart attacks, heart failure, or impairment of memory, language and motor skills. The purpose of this study is to find out if the study drug (pexelizumab), which blocks complement release, can reduce such side effects and be taken safely.
Details:
Eligibility:
Study Type: Interventional, Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: The study population will be drawn from patients undergoing CABG or CABG plus valve surgery using a bypass pump. In addition, they must meet all of the following criteria: - be at least 18 years of age; - have one or more of the following risk factors: -diabetes mellitus; -prior CABG; -the need for urgent intervention, defined according to the American College of Cardiology/ American Heart Association (ACC/AHA) guidelines as being patients who are required to stay in the hospital, but may be scheduled and operated on within a normal scheduling routine, excluding patients who have had a MI within 48 hours of CABG; -female; -history of a neurologic event (cerebrovascular accident, transient ischemic attack or carotid endarterectomy); -history of congestive heart failure (New York Heart Association [NYHA]Class III or IV); -history of 2 myocardial infarctions, or a myocardial infarction that occurred greater than 48 hours but less than four (4) weeks prior to CABG; - provide Informed Consent. EXCLUSION CRITERIA: A patient will be ineligible for study entry if he/she meets any of the following exclusion criteria: - has planned aortic dissection repair and/or requires aortic root reconstruction; - requires salvage intervention as defined by the ACC/AHA guidelines as being ongoing cardiopulmonary resuscitation on the way to the operating room; - has current cardiogenic shock, acute left ventricular rupture, acute septal rupture or acute papillary muscle rupture; - has uncontrolled diabetes, defined as a documented plasma blood glucose value > 400 mg/dl (22.2 mmol/L) within three (3) days before surgery; - has a history of renal failure and a serum creatinine value greater than 3.0 mg/dl; - has a history of chronic hepatic failure and/or hepatic cirrhosis; - has a history of malignancy, excepting basal cell carcinoma and malignancies in remission (greater than 2 years); - has any active bacterial or other infection which is clinically significant, in the opinion of the investigator (e.g. evaluate the evidence based on WBC, temperature, cultures, etc. as appropriate for the patient); - has any serious medical condition which, in the opinion of the investigator is likely to alter the patient’s course of recovery or the evaluation of the study medication’s safety; - has a history of alcohol or drug abuse within the past year; - has a known or suspected hereditary complement deficiency; - has participated in any other investigational drug study or was exposed to an investigational agent or device within 30 days of randomization; - is receiving, or is planning to receive, any other investigational drug or device, or will participate in any other research study during the trial; - is pregnant or breast-feeding.
Total Enrollment: 3000
Location and Contact Information:
Ford Research Center
Pensacola, Florida, 32514
United States
North Ohio Heart Center
Sandusky, Ohio, 44870
United States
Orlando Heart Center
Orlando, Florida, 32806
United States
Brevard Cardiology Group, PA
Merritt Island, Florida, 32953
United States
University Hopital of Cleveland
Cleveland, Ohio, 44106
United States
University of Alabama at Birmingham
Birmingham, Alabama, 35249-6880
United States
Christiana Care Health Services
Newark, Delaware, 19718
United States
Washington Adventist Hospital
Takoma Park, Maryland, 20912
United States
Community Hospital
Indianapolis, Indiana, 46219
United States
Pepin Heart and Vascular Institute
Tampa, Florida, 33613
United States
Legacy Good Samaritan Hospital
Portland, Oregon, 97232
United States
Saguaro Clinical Research
Tucson, Arizona, 85712
United States
South Texas Cardiovascular Consultants Clinical Research Center
San Antonio, Texas, 78229
United States
VA Medical Center - Washington DC
Washington D.C., District of Columbia, 20422
United States
Health Science Centre
Winnipeg, Manitoba, R3E 0Z3
Canada
University of Illinois - Chicago
Chicago, Illinois, 60612
United States
Summa Health Systems
Akron, Ohio, 44309
United States
IMC-Diagnostic and Medical Clinic
Mobile, Alabama, 36604
United States
University of California - Los Angeles
Los Angeles, California, 90095
United States
University of Iowa
Iowa City, Iowa, 52242
United States
Cardiovascular Institute of the South
Houma, Louisiana, 70360
United States
New York Presbyterian Hospital
New York City, New York, 10021
United States
Garden State Cardiology
Paramus, New Jersey, 07652
United States
Sterling Research Group
Cincinnati, Ohio, 45219
United States
Seton Medical Center
Austin, Texas, 78705
United States
Asheville Cardiothoracic Surgeons
Asheville, North Carolina, 28803
United States
Gundersen-Lutheran Hospital
La Crosse, Wisconsin, 54601
United States
VA Medical Center- Atlanta
Decatur, Georgia, 30033
United States
FHS Research Center
Tacoma, Washington, 98405
United States
St. Vincent's Hospital
Los Angeles, California, 90057
United States
VA Medical Center - Dubin
Macon, Georgia, 31208
United States
Hopital Laval
Quebec City, Quebec, G1V 4G5
Canada
Ford Research Center
Pensacola, Florida, 32514
United States
Indiana Ohio Heart
Ft. Wayne, Indiana, 46804
United States
Northside Hospital ans Heart Institute
St. Petersburg, Florida, 33709
United States
University of Louisville
Louisville, Kentucky, 40292
United States
Baystate Medical Center
Springfield, Massachusetts, 01199
United States
Bend Memorial Clinic
Bend, Oregon, 97701
United States
The Chattanooga Heart Institute Cardiovascular Group, P.C.
Chattanooga, Tennessee, 37404
United States
Mary Washington Hospital
Fredericksburg, Virginia,
United States
Turuo Infirmary
New Orleans, Louisiana, 70115
United States
Inova Fairfax Hospital
Falls Church, Virginia, 22043
United States
Medical College of Wisconsin
Milwaukee, Wisconsin, 53295
United States
South Texas VA Health Care
San Antonio, Texas, 78284
United States
Cardiology Associates
Washington D.C., District of Columbia, 20010
United States
VA Medical Center - Houston
Houston, Texas, 77030
United States
Park Nicollet Health Research Center
St. Louis Park, Minnesota, 55426
United States
Albert Einstein Hospital
Bronx, New York, 10461
United States
Park Nicollet Medical Center
Minneapolis, Minnesota, 55416
United States
St. Paul's Hospital
Vancouver, British Columbia, V6Z 1Y6
Canada
Toronto General Hospital
Toronto, Ontario, M5G 2C4
Canada
Cardiovascular Associates of the Delaware Valley
Haddon Heights, New Jersey, 08035
United States
United Health Services
Johnson City, New York, 13790
United States
St. Jude Medical Center
Fullerton, California, 92835
United States
University of Kansas City Medical Center
Kansas City, Kansas, 66160-7378
United States
St. Mary's Duluth Health System
Duluth, Minnesota, 55805
United States
Cardiology Consultants
Pensacola, Florida, 32504
United States
William Beaumont Hospital
Royal Oak, Michigan, 48073
United States
Dayton Heart Center
Dayton, Ohio, 45414
United States
VA-Medical Center -Seattle Cardiology
Seattle, Washington, 98108
United States
Tri Health Bethesda North Hospital
Cincinnati, Ohio, 45242
United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610
United States
Western Cardiology Associates
Denver, Colorado, 80218
United States
University of Montreal
Montreal, Quebec, H2L 4M1
Canada
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213
United States
Florida Cardiovascular Research
Atlantis, Florida, 33462
United States
Morton Plan Mease Health Care
Clearwater, Florida, 33756
United States
Gulf Bay Cardiovascular and Thoracic Associates
Hudson, Florida, 34563
United States
Tallahassee Memorial Regional Medical Center
Tallahassee, Florida, 32308
United States
University of Louisville
Louisville, Kentucky, 40202
United States
North Memorial Hospital
Robbinsdale, Minnesota, 55422
United States
Texas Heart Institute
Houston, Texas, 77030
United States
Northwestern University Medical Center
Chicago, Illinois, 60611
United States
Sarasota Memorial Hospital
Sarasota, Florida, 34239
United States
Christian North East Hospital
St. Louis, Missouri, 63110
United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
United States
Integris Baptist Medical Center
Oklahoma City, Oklahoma, 73112
United States
West Shore Cardiology Research Department
Muskegon, Michigan, 46444
United States
Brotman Medical Center
Beverly Hills, California, 90210
United States
Wisconsin Center for Clinical Research
Milwaukee, Wisconsin, 53215
United States
St. Luke's Hospital - Mid-America Heart Institute
Kansas City, Missouri, 64111
United States
Sentara Norfolk General Hospital
Norfolk, Virginia, 23507
United States
Appleton Medical Center
Appleton, Wisconsin, 54911
United States
Abbott Northwestern Hospital
Minneapolis, Minnesota, 55407
United States
Duke University Medical Center
Durham, North Carolina, 27710
United States
Tri-City Medical Center
Oceanside, California, 92056
United States
Rochester General Hospital
Rochester, New York, 14621
United States
Methodist Hospital
New Orleans, Louisiana, 70118
United States
Camcare Health Education & Research Institute
Charleston, West Virginia, 25304
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78284
United States
Massachusetts General Hospital
Boston, Massachusetts, 02114
United States
Southern Arizona VAMC
Tucson, Arizona, 85723
United States
Mercy General Hospital
Sacramento, California, 95819
United States
Alton Ochsner Medical Foundation - Brent House
New Orleans, Louisiana, 70121
United States
MIMA Century Research Associates
Melbourne, Florida, 32901
United States
San Diego Cardiac Center
San Diego, California, 92123
United States
South Denver Cardiology Associates
Denver, Colorado, 80111
United States
Brackenridge Hospital
Austin, Texas, 78701
United States
St. Joseph's Hospital
Atlanta, Georgia, 30342
United States
West forest School of Medicine
Winston Salem, North Carolina, 27157
United States
Guthrie Clinical Research
Sayre, Pennsylvania, 18840
United States
Methodist Hospital
Houston, Texas, 77030
United States
Maimonides Medical Center
Brooklyn, New York, 11219
United States
Cardiovascular Associates of the Peninsula
Burlingame, California, 94401
United States
Cardiovascular Associates of the Delaware Valley
Haddon Heights, New Jersey, 08035
United States
Cardiovascular Research and Education Foundation, Inc.
Wausau, Wisconsin, 54401
United States
Carillion Roanoke Hospital
Roanoke, Virginia, 24014
United States
Heart and Vascular Clinic of Northern CO
Fort Collins, Colorado, 80528
United States
Wesley Medical Center
Wichita, Kansas, 67214
United States
Crozer-Chester Medical Center
Oakland, California, 94609-3102
United States
Cardiovascular Institute of the South
Houma, Louisiana, 70360
United States
Kaiser Foundation Hospital
San Francisco, California, 94115
United States
McMaster Clinic
Hamilton, Ontario, L8L 2X2
Canada
Akron General Medical Center
Akron, Ohio, 44307
United States
Sparks Regional Medical Center
Fort Smith, Arkansas, 72901
United States
Westchester County Medical Center
Valhalla, New York, 10595
United States
Sinai Hospital of Baltimore
Baltimore, Maryland, 21215
United States
New Brunswick Heart Center
St. John, New Brunswick, E2L 4L2
Canada
University of Massachusetts
Worcester, Massachusetts, 01655
United States
Cardiovascular Institute of the South
Thibodaux, Louisiana, 70301
United States
North Memorial Pain Institute
Philadelphia, Pennsylvania, 19102
United States
Huntington Memorial Hospital
Los Angeles, California, 90033
United States
Oklahoma Foundation for Cardiovascular Research
Oklahoma City, Oklahoma, 73104
United States
Mt. Carmel West
Columbus, Ohio, 43222
United States
Washington Hospital Center
Washington D.C., District of Columbia, 20010
United States
Northwestern Univ. Medical Center
Chicago, Illinois, 60611
United States
Good Samaritan Hospital -Seton Center
Cincinnati, Ohio, 45220
United States
Desert Samaritan - Lutheran Heart
Mesa, Arizona, 85202
United States
UCSF Moffitt-Long Hospital
San Francisco, California, 94143
United States
St. Vincent's Medical Center
Bridgeport, Connecticut, 06606
United States
Apex Cardiology
Inglewood, California, 90301
United States
The Heart Center
Doylestown, Pennsylvania, 18901
United States
Cardiology diagnostics, Ltd.
St. Peters, Missouri, 63376
United States
Texas Tech University Health Center
Lubbock, Texas, 79430
United States
Regina General Hospital
Regina, Saskatchewan, S4P 0W5
Canada
Georgetown University Hospital
Washington D.C., District of Columbia, 20007
United States
Tacoma General Hospital
Tacoma, Washington, 98405
United States
Dalhousie University
Halifax, Nova Scotia, B3H 3A7
Canada
University of Washington
Seattle, Washington, 98195
United States
Royal Victoria Hospital
Montreal, Quebec, H3A 1A1
Canada
Fletcher Allen Health Care
Burlington, Vermont, 05401
United States
Midatlantic Cardiovascular Associates
Towson, Maryland, 21204
United States
Makenzie Health Science Center
Edmonton, Alberta, T6G 2B7
Canada
Iowa Heart Center - Laurel
Des Moines, Iowa, 50314
United States
St. Joseph's Hospital
Towson, Maryland, 21204
United States
Washington University School of Medicine
St. Louis, Missouri, 63110
United States
Kaiser Permanente Medical Center
Honolulu, Hawaii, 96819
United States
University of Rochester
Rochester, New York, 14642
United States
Sunnybrook & Women's College Health Science Centre
Toronto, Ontario, M4N 3M5
Canada
Florida Heart Institute at Florida Hospital
Orlando, Florida, 32803
United States
Northwest Surgical Associates
Portland, Oregon, 97210
United States
Emory University Hospital
Atlanta, Georgia, 30322
United States
McLaren Regional Medical Center
Flint, Michigan, 48532
United States
St. Luke's Hospital-Duluth
Duluth, Minnesota, 55805
United States
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756
United States
Good Samaritan Regional Medical Center
Phoenix, Arizona, 85006
United States
Brigham and Womens Hospital
Boston, Massachusetts, 02115
United States
University Hospital
Augusta, Georgia, 30901
United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96813-3009
United States
Covenant Medical Center
Saginaw, Michigan, 48602
United States
Henry Ford Hospital
Detroit, Michigan, 48202
United States
Evanston Northwestern Healthcare Evanston Hospital
Evanston, Illinois, 60201
United States
St. Vincent's Medical Center
Indianapolis, Indiana, 46260
United States
Cardiac Centers of Louisiana
Shreveport, Louisiana, 711033
United States
Baptist Memorial Hospital
Memphis, Tennessee, 38120
United States
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1C6
Canada
Cathy Metcalfe Research Consultants
Delta, British Columbia, B4K 2G5
Canada
Montreal Heart Institute
Montreal, Quebec, H1T 1C8
Canada
University of Oklahoma
Oklahoma City, Oklahoma, 73104
United States
University of Louisville
Louisville, Kentucky, 40292
United States
Mississippi Center for Clinical Research
Jackson, Mississippi, 32216
United States
Scott and White Memorial Hospital
Temple, Texas, 76508
United States
General Hospital Health Science Center
St. John's, Newfoundland and Labrador, A1B 3V6
Canada
Baptist Medical Center Cardiology
Birmingham, Alabama, 35211
United States
University of Southern California
Los Angeles, California, 90033
United States
Seton Medical Center
Daly City, California, 94015
United States
Victoria Heart Institute
Victoria, British Columbia, V8R 4R2
Canada
University of Arkansas
Little Rock, Arkansas, 72205
United States
University of Manitoba Health Science Centre
Winnipeg, Manitoba, R2H 2A6
Canada
Heart Group Research
Ft. Lauderdale, Florida, 33308
United States
Union Memorial Hospital
Baltimore, Maryland, 21218
United States
Good Samaritan Hospital
Cincinnati, Ohio, 45219
United States
Wisconsin Center for Clinical Research
Milwaukee, Wisconsin, 53215
United States
Thoracic and Cardiovascular Institute
Lansing, Michigan, 48919
United States
Parkway Cardiovascular Associates
Oak Ridge, Tennessee, 37830
United States
University of Arizona
Tucson, Arizona, 85724
United States
Chester County Cardiovascular Center
West Chester, Pennsylvania, 19380
United States
Medical Research Unlimited
Miami, Florida, 33125
United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216
United States
Cardiovascular and Thoracic Surgery Associates
Arlington, Virginia, 22205
United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390
United States
Additional Information:
Study ID Numbers: 2000099; PRIMO-CABG
Study Start Date: January 2002
Record last reviewed: February 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00048308
Other Cardio-Pulmonary Bypass Studies:
1. Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass
Related Studies:
Other Cardio-pulmonary Bypass Clinical Trials
Other Kansas Clinical Trials
Other Kansas City Clinical Trials
Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass
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