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Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass Clinical research trials and Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass. Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass clinical trial. Participants oftentimes recieve the finest healthcare available for their Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.

Home > "E" Clinical Trials Conditions > Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass

Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass



Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass

For Condition: Cardio-pulmonary Bypass,Coronary Artery Bypass Graft
Status: No longer recruiting
Sponsor(s): Alexion Pharmaceuticals ,
Synopsis: During a heart bypass procedure, a substance called "complement" is released by the body. This complement causes inflammation, which can lead to side effects such as chest pain, heart attacks, heart failure, or impairment of memory, language and motor skills. The purpose of this study is to find out if the study drug (pexelizumab), which blocks complement release, can reduce such side effects and be taken safely.
Details:
Eligibility:
Study Type:
  Interventional, Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: The study population will be drawn from patients undergoing CABG or CABG plus valve surgery using a bypass pump. In addition, they must meet all of the following criteria: - be at least 18 years of age; - have one or more of the following risk factors: -diabetes mellitus; -prior CABG; -the need for urgent intervention, defined according to the American College of Cardiology/ American Heart Association (ACC/AHA) guidelines as being patients who are required to stay in the hospital, but may be scheduled and operated on within a normal scheduling routine, excluding patients who have had a MI within 48 hours of CABG; -female; -history of a neurologic event (cerebrovascular accident, transient ischemic attack or carotid endarterectomy); -history of congestive heart failure (New York Heart Association [NYHA]Class III or IV); -history of 2 myocardial infarctions, or a myocardial infarction that occurred greater than 48 hours but less than four (4) weeks prior to CABG; - provide Informed Consent. EXCLUSION CRITERIA: A patient will be ineligible for study entry if he/she meets any of the following exclusion criteria: - has planned aortic dissection repair and/or requires aortic root reconstruction; - requires salvage intervention as defined by the ACC/AHA guidelines as being ongoing cardiopulmonary resuscitation on the way to the operating room; - has current cardiogenic shock, acute left ventricular rupture, acute septal rupture or acute papillary muscle rupture; - has uncontrolled diabetes, defined as a documented plasma blood glucose value > 400 mg/dl (22.2 mmol/L) within three (3) days before surgery; - has a history of renal failure and a serum creatinine value greater than 3.0 mg/dl; - has a history of chronic hepatic failure and/or hepatic cirrhosis; - has a history of malignancy, excepting basal cell carcinoma and malignancies in remission (greater than 2 years); - has any active bacterial or other infection which is clinically significant, in the opinion of the investigator (e.g. evaluate the evidence based on WBC, temperature, cultures, etc. as appropriate for the patient); - has any serious medical condition which, in the opinion of the investigator is likely to alter the patient’s course of recovery or the evaluation of the study medication’s safety; - has a history of alcohol or drug abuse within the past year; - has a known or suspected hereditary complement deficiency; - has participated in any other investigational drug study or was exposed to an investigational agent or device within 30 days of randomization; - is receiving, or is planning to receive, any other investigational drug or device, or will participate in any other research study during the trial; - is pregnant or breast-feeding.
Total Enrollment: 3000

Location and Contact Information:

Ford Research Center
Pensacola,  Florida,  32514
United States
 

North Ohio Heart Center
Sandusky,  Ohio,  44870
United States
 

Orlando Heart Center
Orlando,  Florida,  32806
United States
 

Brevard Cardiology Group, PA
Merritt Island,  Florida,  32953
United States
 

University Hopital of Cleveland
Cleveland,  Ohio,  44106
United States
 

University of Alabama at Birmingham
Birmingham,  Alabama,  35249-6880
United States
 

Christiana Care Health Services
Newark,  Delaware,  19718
United States
 

Washington Adventist Hospital
Takoma Park,  Maryland,  20912
United States
 

Community Hospital
Indianapolis,  Indiana,  46219
United States
 

Pepin Heart and Vascular Institute
Tampa,  Florida,  33613
United States
 

Legacy Good Samaritan Hospital
Portland,  Oregon,  97232
United States
 

Saguaro Clinical Research
Tucson,  Arizona,  85712
United States
 

South Texas Cardiovascular Consultants Clinical Research Center
San Antonio,  Texas,  78229
United States
 

VA Medical Center - Washington DC
Washington D.C.,  District of Columbia,  20422
United States
 

Health Science Centre
Winnipeg,  Manitoba,  R3E 0Z3
Canada
 

University of Illinois - Chicago
Chicago,  Illinois,  60612
United States
 

Summa Health Systems
Akron,  Ohio,  44309
United States
 

IMC-Diagnostic and Medical Clinic
Mobile,  Alabama,  36604
United States
 

University of California - Los Angeles
Los Angeles,  California,  90095
United States
 

University of Iowa
Iowa City,  Iowa,  52242
United States
 

Cardiovascular Institute of the South
Houma,  Louisiana,  70360
United States
 

New York Presbyterian Hospital
New York City,  New York,  10021
United States
 

Garden State Cardiology
Paramus,  New Jersey,  07652
United States
 

Sterling Research Group
Cincinnati,  Ohio,  45219
United States
 

Seton Medical Center
Austin,  Texas,  78705
United States
 

Asheville Cardiothoracic Surgeons
Asheville,  North Carolina,  28803
United States
 

Gundersen-Lutheran Hospital
La Crosse,  Wisconsin,  54601
United States
 

VA Medical Center- Atlanta
Decatur,  Georgia,  30033
United States
 

FHS Research Center
Tacoma,  Washington,  98405
United States
 

St. Vincent's Hospital
Los Angeles,  California,  90057
United States
 

VA Medical Center - Dubin
Macon,  Georgia,  31208
United States
 

Hopital Laval
Quebec City,  Quebec,  G1V 4G5
Canada
 

Ford Research Center
Pensacola,  Florida,  32514
United States
 

Indiana Ohio Heart
Ft. Wayne,  Indiana,  46804
United States
 

Northside Hospital ans Heart Institute
St. Petersburg,  Florida,  33709
United States
 

University of Louisville
Louisville,  Kentucky,  40292
United States
 

Baystate Medical Center
Springfield,  Massachusetts,  01199
United States
 

Bend Memorial Clinic
Bend,  Oregon,  97701
United States
 

The Chattanooga Heart Institute Cardiovascular Group, P.C.
Chattanooga,  Tennessee,  37404
United States
 

Mary Washington Hospital
Fredericksburg,  Virginia, 
United States
 

Turuo Infirmary
New Orleans,  Louisiana,  70115
United States
 

Inova Fairfax Hospital
Falls Church,  Virginia,  22043
United States
 

Medical College of Wisconsin
Milwaukee,  Wisconsin,  53295
United States
 

South Texas VA Health Care
San Antonio,  Texas,  78284
United States
 

Cardiology Associates
Washington D.C.,  District of Columbia,  20010
United States
 

VA Medical Center - Houston
Houston,  Texas,  77030
United States
 

Park Nicollet Health Research Center
St. Louis Park,  Minnesota,  55426
United States
 

Albert Einstein Hospital
Bronx,  New York,  10461
United States
 

Park Nicollet Medical Center
Minneapolis,  Minnesota,  55416
United States
 

St. Paul's Hospital
Vancouver,  British Columbia,  V6Z 1Y6
Canada
 

Toronto General Hospital
Toronto,  Ontario,  M5G 2C4
Canada
 

Cardiovascular Associates of the Delaware Valley
Haddon Heights,  New Jersey,  08035
United States
 

United Health Services
Johnson City,  New York,  13790
United States
 

St. Jude Medical Center
Fullerton,  California,  92835
United States
 

University of Kansas City Medical Center
Kansas City,  Kansas,  66160-7378
United States
 

St. Mary's Duluth Health System
Duluth,  Minnesota,  55805
United States
 

Cardiology Consultants
Pensacola,  Florida,  32504
United States
 

William Beaumont Hospital
Royal Oak,  Michigan,  48073
United States
 

Dayton Heart Center
Dayton,  Ohio,  45414
United States
 

VA-Medical Center -Seattle Cardiology
Seattle,  Washington,  98108
United States
 

Tri Health Bethesda North Hospital
Cincinnati,  Ohio,  45242
United States
 

Bridgeport Hospital
Bridgeport,  Connecticut,  06610
United States
 

Western Cardiology Associates
Denver,  Colorado,  80218
United States
 

University of Montreal
Montreal,  Quebec,  H2L 4M1
Canada
 

University of Pittsburgh Medical Center
Pittsburgh,  Pennsylvania,  15213
United States
 

Florida Cardiovascular Research
Atlantis,  Florida,  33462
United States
 

Morton Plan Mease Health Care
Clearwater,  Florida,  33756
United States
 

Gulf Bay Cardiovascular and Thoracic Associates
Hudson,  Florida,  34563
United States
 

Tallahassee Memorial Regional Medical Center
Tallahassee,  Florida,  32308
United States
 

University of Louisville
Louisville,  Kentucky,  40202
United States
 

North Memorial Hospital
Robbinsdale,  Minnesota,  55422
United States
 

Texas Heart Institute
Houston,  Texas,  77030
United States
 

Northwestern University Medical Center
Chicago,  Illinois,  60611
United States
 

Sarasota Memorial Hospital
Sarasota,  Florida,  34239
United States
 

Christian North East Hospital
St. Louis,  Missouri,  63110
United States
 

Allegheny General Hospital
Pittsburgh,  Pennsylvania,  15212
United States
 

Integris Baptist Medical Center
Oklahoma City,  Oklahoma,  73112
United States
 

West Shore Cardiology Research Department
Muskegon,  Michigan,  46444
United States
 

Brotman Medical Center
Beverly Hills,  California,  90210
United States
 

Wisconsin Center for Clinical Research
Milwaukee,  Wisconsin,  53215
United States
 

St. Luke's Hospital - Mid-America Heart Institute
Kansas City,  Missouri,  64111
United States
 

Sentara Norfolk General Hospital
Norfolk,  Virginia,  23507
United States
 

Appleton Medical Center
Appleton,  Wisconsin,  54911
United States
 

Abbott Northwestern Hospital
Minneapolis,  Minnesota,  55407
United States
 

Duke University Medical Center
Durham,  North Carolina,  27710
United States
 

Tri-City Medical Center
Oceanside,  California,  92056
United States
 

Rochester General Hospital
Rochester,  New York,  14621
United States
 

Methodist Hospital
New Orleans,  Louisiana,  70118
United States
 

Camcare Health Education & Research Institute
Charleston,  West Virginia,  25304
United States
 

University of Texas Health Science Center at San Antonio
San Antonio,  Texas,  78284
United States
 

Massachusetts General Hospital
Boston,  Massachusetts,  02114
United States
 

Southern Arizona VAMC
Tucson,  Arizona,  85723
United States
 

Mercy General Hospital
Sacramento,  California,  95819
United States
 

Alton Ochsner Medical Foundation - Brent House
New Orleans,  Louisiana,  70121
United States
 

MIMA Century Research Associates
Melbourne,  Florida,  32901
United States
 

San Diego Cardiac Center
San Diego,  California,  92123
United States
 

South Denver Cardiology Associates
Denver,  Colorado,  80111
United States
 

Brackenridge Hospital
Austin,  Texas,  78701
United States
 

St. Joseph's Hospital
Atlanta,  Georgia,  30342
United States
 

West forest School of Medicine
Winston Salem,  North Carolina,  27157
United States
 

Guthrie Clinical Research
Sayre,  Pennsylvania,  18840
United States
 

Methodist Hospital
Houston,  Texas,  77030
United States
 

Maimonides Medical Center
Brooklyn,  New York,  11219
United States
 

Cardiovascular Associates of the Peninsula
Burlingame,  California,  94401
United States
 

Cardiovascular Associates of the Delaware Valley
Haddon Heights,  New Jersey,  08035
United States
 

Cardiovascular Research and Education Foundation, Inc.
Wausau,  Wisconsin,  54401
United States
 

Carillion Roanoke Hospital
Roanoke,  Virginia,  24014
United States
 

Heart and Vascular Clinic of Northern CO
Fort Collins,  Colorado,  80528
United States
 

Wesley Medical Center
Wichita,  Kansas,  67214
United States
 

Crozer-Chester Medical Center
Oakland,  California,  94609-3102
United States
 

Cardiovascular Institute of the South
Houma,  Louisiana,  70360
United States
 

Kaiser Foundation Hospital
San Francisco,  California,  94115
United States
 

McMaster Clinic
Hamilton,  Ontario,  L8L 2X2
Canada
 

Akron General Medical Center
Akron,  Ohio,  44307
United States
 

Sparks Regional Medical Center
Fort Smith,  Arkansas,  72901
United States
 

Westchester County Medical Center
Valhalla,  New York,  10595
United States
 

Sinai Hospital of Baltimore
Baltimore,  Maryland,  21215
United States
 

New Brunswick Heart Center
St. John,  New Brunswick,  E2L 4L2
Canada
 

University of Massachusetts
Worcester,  Massachusetts,  01655
United States
 

Cardiovascular Institute of the South
Thibodaux,  Louisiana,  70301
United States
 

North Memorial Pain Institute
Philadelphia,  Pennsylvania,  19102
United States
 

Huntington Memorial Hospital
Los Angeles,  California,  90033
United States
 

Oklahoma Foundation for Cardiovascular Research
Oklahoma City,  Oklahoma,  73104
United States
 

Mt. Carmel West
Columbus,  Ohio,  43222
United States
 

Washington Hospital Center
Washington D.C.,  District of Columbia,  20010
United States
 

Northwestern Univ. Medical Center
Chicago,  Illinois,  60611
United States
 

Good Samaritan Hospital -Seton Center
Cincinnati,  Ohio,  45220
United States
 

Desert Samaritan - Lutheran Heart
Mesa,  Arizona,  85202
United States
 

UCSF Moffitt-Long Hospital
San Francisco,  California,  94143
United States
 

St. Vincent's Medical Center
Bridgeport,  Connecticut,  06606
United States
 

Apex Cardiology
Inglewood,  California,  90301
United States
 

The Heart Center
Doylestown,  Pennsylvania,  18901
United States
 

Cardiology diagnostics, Ltd.
St. Peters,  Missouri,  63376
United States
 

Texas Tech University Health Center
Lubbock,  Texas,  79430
United States
 

Regina General Hospital
Regina,  Saskatchewan,  S4P 0W5
Canada
 

Georgetown University Hospital
Washington D.C.,  District of Columbia,  20007
United States
 

Tacoma General Hospital
Tacoma,  Washington,  98405
United States
 

Dalhousie University
Halifax,  Nova Scotia,  B3H 3A7
Canada
 

University of Washington
Seattle,  Washington,  98195
United States
 

Royal Victoria Hospital
Montreal,  Quebec,  H3A 1A1
Canada
 

Fletcher Allen Health Care
Burlington,  Vermont,  05401
United States
 

Midatlantic Cardiovascular Associates
Towson,  Maryland,  21204
United States
 

Makenzie Health Science Center
Edmonton,  Alberta,  T6G 2B7
Canada
 

Iowa Heart Center - Laurel
Des Moines,  Iowa,  50314
United States
 

St. Joseph's Hospital
Towson,  Maryland,  21204
United States
 

Washington University School of Medicine
St. Louis,  Missouri,  63110
United States
 

Kaiser Permanente Medical Center
Honolulu,  Hawaii,  96819
United States
 

University of Rochester
Rochester,  New York,  14642
United States
 

Sunnybrook & Women's College Health Science Centre
Toronto,  Ontario,  M4N 3M5
Canada
 

Florida Heart Institute at Florida Hospital
Orlando,  Florida,  32803
United States
 

Northwest Surgical Associates
Portland,  Oregon,  97210
United States
 

Emory University Hospital
Atlanta,  Georgia,  30322
United States
 

McLaren Regional Medical Center
Flint,  Michigan,  48532
United States
 

St. Luke's Hospital-Duluth
Duluth,  Minnesota,  55805
United States
 

Dartmouth-Hitchcock Medical Center
Lebanon,  New Hampshire,  03756
United States
 

Good Samaritan Regional Medical Center
Phoenix,  Arizona,  85006
United States
 

Brigham and Womens Hospital
Boston,  Massachusetts,  02115
United States
 

University Hospital
Augusta,  Georgia,  30901
United States
 

Straub Clinic and Hospital
Honolulu,  Hawaii,  96813-3009
United States
 

Covenant Medical Center
Saginaw,  Michigan,  48602
United States
 

Henry Ford Hospital
Detroit,  Michigan,  48202
United States
 

Evanston Northwestern Healthcare Evanston Hospital
Evanston,  Illinois,  60201
United States
 

St. Vincent's Medical Center
Indianapolis,  Indiana,  46260
United States
 

Cardiac Centers of Louisiana
Shreveport,  Louisiana,  711033
United States
 

Baptist Memorial Hospital
Memphis,  Tennessee,  38120
United States
 

Vancouver General Hospital
Vancouver,  British Columbia,  V5Z 1C6
Canada
 

Cathy Metcalfe Research Consultants
Delta,  British Columbia,  B4K 2G5
Canada
 

Montreal Heart Institute
Montreal,  Quebec,  H1T 1C8
Canada
 

University of Oklahoma
Oklahoma City,  Oklahoma,  73104
United States
 

University of Louisville
Louisville,  Kentucky,  40292
United States
 

Mississippi Center for Clinical Research
Jackson,  Mississippi,  32216
United States
 

Scott and White Memorial Hospital
Temple,  Texas,  76508
United States
 

General Hospital Health Science Center
St. John's,  Newfoundland and Labrador,  A1B 3V6
Canada
 

Baptist Medical Center Cardiology
Birmingham,  Alabama,  35211
United States
 

University of Southern California
Los Angeles,  California,  90033
United States
 

Seton Medical Center
Daly City,  California,  94015
United States
 

Victoria Heart Institute
Victoria,  British Columbia,  V8R 4R2
Canada
 

University of Arkansas
Little Rock,  Arkansas,  72205
United States
 

University of Manitoba Health Science Centre
Winnipeg,  Manitoba,  R2H 2A6
Canada
 

Heart Group Research
Ft. Lauderdale,  Florida,  33308
United States
 

Union Memorial Hospital
Baltimore,  Maryland,  21218
United States
 

Good Samaritan Hospital
Cincinnati,  Ohio,  45219
United States
 

Wisconsin Center for Clinical Research
Milwaukee,  Wisconsin,  53215
United States
 

Thoracic and Cardiovascular Institute
Lansing,  Michigan,  48919
United States
 

Parkway Cardiovascular Associates
Oak Ridge,  Tennessee,  37830
United States
 

University of Arizona
Tucson,  Arizona,  85724
United States
 

Chester County Cardiovascular Center
West Chester,  Pennsylvania,  19380
United States
 

Medical Research Unlimited
Miami,  Florida,  33125
United States
 

Jacksonville Center for Clinical Research
Jacksonville,  Florida,  32216
United States
 

Cardiovascular and Thoracic Surgery Associates
Arlington,  Virginia,  22205
United States
 

University of Texas Southwestern Medical Center
Dallas,  Texas,  75390
United States
 


Additional Information:
Study ID Numbers:
  2000099;  PRIMO-CABG
Study Start Date: January 2002
Record last reviewed: February 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00048308

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1. Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery with Cardio-Pulmonary Bypass

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