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Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation



Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation

For Condition: Hyperinsulinemia
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli.
Details: Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli.
Eligibility:
Study Type:
  Interventional, Treatment, Safety
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Between 40-65 years old. No medications. No medical problems. No serum cholesterol levels below 200 mg/dl. No contraceptives.
Total Enrollment: 16

Location and Contact Information:

National Heart, Lung and Blood Institute (NHLBI)
Bethesda,  Maryland,  20892
United States
 


Additional Information:
Study ID Numbers:
  970100;  97-H-0100
Study Start Date: March 26, 1997
Record last reviewed: February 19, 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001624

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4. Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation

5. Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients with Insulin and Fat Abnormalities

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