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Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea Clinical research trials and Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea. Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea clinical trial. Participants typically obtain the most effective healthcare available for their Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "D" Clinical Trials Conditions > Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea  Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea
Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea
For Condition: Diarrhea,HIV Infections
Status: Completed
Sponsor(s): VA Medical Center-Gainesville ,
Synopsis: To perform preliminary clinical testing of diethylhomospermine (DEHSPM), a polyamine analogue, for refractory AIDS-related diarrhea. Possibly, DEHSPM will reduce stool volume and frequency in patients with refractory AIDS-related diarrhea.
Details: Possibly, DEHSPM will reduce stool volume and frequency in patients with refractory AIDS-related diarrhea. Patients are initially hydrated for 24 hours, followed by a 3-day baseline period. They then receive intravenous infusions of DEHSPM three times per day for 3 days, followed by observation for 3 days.
Eligibility:
Study Type: Interventional, Treatment, Open Label, Safety Study
Minimum Age/Maximum Age: 18 Years/65 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients must have: - ARC or AIDS by CDC criteria. - Uncontrolled diarrhea unresponsive to high-dose, nonspecific antidiarrheal therapy. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: - Known idiopathic ulcerative colitis or Crohn colitis. - Acute stool-culture-positive bacterial colitis. - Acute amoebic colitis. - Pseudomembranous colitis with Clostridium difficile toxin positivity. - Short-gut syndrome. - Chronic pancreatitis. - Ischemic bowel disease. - Enteroenteric fistulae. - Other gastrointestinal tract disorders known to cause diarrhea. - Underlying evidence of immunosuppression other than that related to HIV infection. - Unable or unwilling to have subcutaneous injections. - Clinically significant CNS, hepatic, or renal disease. Concurrent Medication: Excluded: - Other experimental antidiarrheal drugs. - Antibiotic therapy. Prior Medication: Excluded: - Other experimental drugs within 1 month prior to study entry. Required: - At least 2 weeks of prior high-dose, nonspecific antidiarrheal therapy (i.e., loperamide, diphenoxylate hydrochloride-atropine sulfate, or opiates) at maximally tolerable doses.
Total Enrollment:
Location and Contact Information:
Gainesville Veterans Administration Med Ctr
Gainesville, Florida, 32608
United States
Additional Information:
Study ID Numbers: 223A;
Study Start Date:
Record last reviewed: April 1996
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002121
Other Diarrhea Studies:
1. A Study of Rifabutin, Used Alone or with Ethambutol in the Prevention of Mycobacterium avium Complex (MAC) Bacteremia in Patients with AIDS
2. Evaluation of the Therapeutic Benefit of r-metHuIFN- gamma in AIDS Patients With Disseminated Mycobacterium Avium-Intracellulare (MAI) Infection: A Multi-Centered Pilot Study
3. Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients with AIDS Who Have CMV Retinitis
4. Atazanavir Versus Lopinavir/Ritonavir (LPV/RTV) in Patients Who Have Not Had Success with Protease Inhibitor-Containing HAART Regimen(s)
5. A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate (Neutrexin) With Leucovorin Protection for European Adult Patients (>= 13 Years Old) With Pneumocystis carinii Pneumonia
Related Studies:
Other Diarrhea Clinical Trials
Other Florida Clinical Trials
Other Gainesville Clinical Trials
Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea
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