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Home > "D" Clinical Trials Conditions > Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents  Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents
Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents
For Condition: Tourette Syndrome,Obsessive Compulsive Disorder
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , Yale University
Synopsis: OBJECTIVES: I. Characterize the natural history, associated features, and severity of symptoms of obsessive compulsive disorder and Tourette syndrome in children and adolescents. II. Identify factors that influence the clinical course and prognosis of these patients.
Details: PROTOCOL OUTLINE: All patients and their families participate in 6 parts of the study: current severity of symptoms, coincident disease diagnoses, natural history, neuropsychologic assessment, physical and neurologic assessment, and family history and function. The evaluations include the following: Current Severity of Symptoms Assessment, Children's Yale Brown Obsessive Compulsive Scale (CY-BOCS), Clinician's Global Impression-Obsessive Compulsive Disorder (CGI-OC), Leyton Obsessional Inventory-Child Version (LOI-CV), Obsessive Compulsive Personality Rating Scale, Yale Global Tic Severity Scale(YGTSS), Clinician's Global Impression-Tourette Syndrome (CGI-TS), Tourette Syndrome Symptom List (TSSL), Clinician's Global Impression-Anxiety (CGI-A), Covi Anxiety Scale (CAS), Children's Manifest Anxiety Scale-Revised (CMAS-R), Social Anxiety Scale for Children-Revised, Fear Survey Schedule for Children-Revised, Louisville Fear Survey, Children's Depression Rating Scale-Revised (CDRS-R), Clinician's Global Impression-Depression (CGI-D), Children's Depression Inventory (CDI), The Dimensions of Temperament Survey (DOTS), Mosher Guilt Scale-Revised, Real vs. Ideal Self Questionnaire, Harter Self-Perception Profile For Children, The Children's Global Assessment Scale (CGAS), The Child Behavior Checklist (CBCL), Coincident Disease Diagnoses Assessment, Diagnostic Interview Schedule for Children-II (DISC-II), Yale Best Estimate of Diagnoses Schedule (Y-BEDS), Natural History Evaluation, Yale Natural History Questionnaire (YHNQ), Social Readjustment Scale for Children, Neuropsychologic Assessment, Delayed Response Tasks, Continuous Performance Task, Continuous Recognition Memory, Selective Reminding Procedures, Card Sorting Tasks, Wechsler Intelligence Scale for Children-Revised, Digit Span, Digit Symbol and Mazes Paced Auditory, Serial Addition Task, Purdue Pegboard Trail Making Tasks, Fluency Tasks, Rey-Osterreith Complex Figure Stanford-Binet Intelligence Scale-Fourth Edition, Physical, Neurologic, and Neurochemical Assessment Physical exam (abbreviated), Physical and Neurological Examination for Soft Signs (PANESS), 24-hour urinary cortisol and catecholamines, Family History and Family Function Assessment of family history, Assessment of Family Functioning. The estimated duration of study is 10 years.
Eligibility:
Study Type: Observational, Screening
Minimum Age/Maximum Age: 5 Years/17 Years
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Obsessive compulsive disorder or Tourette syndrome meeting Diagnostic and Statistical Manual of Mental Disorders IV criteria
Total Enrollment: 90
Location and Contact Information:
Overall Study Official:
JamesLeckman, Study Chair, Yale University
Yale University School of Medicine
New Haven, Connecticut, 06520-8035
United States
Additional Information:
Study ID Numbers: NCRR-M01RR06022-5099; YALESM-5099
Study Start Date: December 1989
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004324
Other Tourette Syndrome Studies:
1. Magnetic Resonance Spectroscopy to Evaluate Tourette's Syndrome
2. Brain Dynamics Involved in Generating Tics and Controlling Voluntary Movement
3. Study of Tics in Patients with Tourette's Syndrome and Chronic Motor Tic Disorder
4. I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers
5. Study of the Neurobiology of Tourette Syndrome and Related Disorders
Related Studies:
Other Tourette Syndrome Clinical Trials
Other Connecticut Clinical Trials
Other New Haven Clinical Trials
Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents
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