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Depakote ER plus an atypical antipsychotic vs. an atypical antipsychotic alone in the treatment of schizophrenia



Depakote ER plus an atypical antipsychotic vs. an atypical antipsychotic alone in the treatment of schizophrenia

For Condition: Schizophrenia
Status: Recruiting
Sponsor(s): Abbott Laboratories ,
Synopsis: The purpose of this study is to assess the 14-day and 12-week safety and efficacy of Depakote ER used in combination with either olanzapine or risperidone versus antipsychotic monotherapy with olanzapine or risperidone for the treatment of schizophrenia.
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/65 Years
Genders: Both
Protocol Entry Criteria: KEY INCLUSION CRITERIA - Acute exacerbation of schizophrenia as defined by: subject recently hospitalized or is in the process of being admitted to a hospital or an acute care inpatient psychiatric treatment facility; and has a PANNS Total score of 70 or greater at the time of screening and at randomization based on a 1-7 point scale; and has a score on any two of the four items from psychoisis cluster of the BPRS (extracted from the PANSS) that correspond to the positive symptoms (hallucinatory behavior, unusual thought content, sonceptual disorganization and suspiciousness) totaling 8 or greater; and has a total of 6 or greater on one of the following two pairs of items from the BPRS (extracted from the PANSS): hostility and uncooperativeness or excitememtn and tension. - Current DSM-IV-TR diagnosis of schizophrenia as confirmed by the SCID - Positive response to antipsychotics in the previous 2 years KEY EXCLUSION CRITERIA - Current diagnosis of schizoaffective disorder, drug-induced psychosis, manic episode or major depressive episode. - At the time of screening, has been hospitalized for more than 14 days for the current episode - Has ever taken clozapine - Has had more than 3 psychiatric hospitalizations in the previous 6 months or has had more than 8 weeks of psychiatric hospitalization in the previous 12 months - Has serious violent, homicidal, suicidal ideation - Has received depot medictions fluphenazine decanoate and/or haloperidon decanoate within 2 or 4 weeks prior to randomization respectively - Urine toxicology screen is positive for phencyclidine (PCP), opiates, cocaine or amphetamines - History of alcohol or substance dependence within the past month - Has taken any valproate product for a psychiatric indication within the previous 30 days - Has received an investigational drug within the last 30 days
Total Enrollment: 

Location and Contact Information:


Additional Information:
Study ID Numbers:
  M02-547; 
Study Start Date: 
Record last reviewed: November 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00073164

Other Schizophrenia Studies:
1. Comparison of Clozapine or Olanzapine in Childhood-Onset Psychotic Disorders

2. Cognitive - Behavioral Therapy

3. Treatment of Schizophrenia Through Internet-Based Psychoeducation

4. Efficacy and safety of two atypical antipsychotics vs. placebo in patients with an acute exacerbation of either schizophrenia or schizoaffective disorder

5. Glycine and D-Cycloserine in Schizophrenia

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Depakote ER plus an atypical antipsychotic vs. an atypical antipsychotic alone in the treatment of schizophrenia

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