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Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children Clinical Trials Information presented on Clinical Trials Search is not intended to be a substitute for qualified health advice, trips or treatment by using a genuine doctor. We aren't doctors. Always consult your mD on Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children Clinical research trials and Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children health trials take place in a lot of of cities across the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the potency of new drugs. The aim of the studies / projects is to answer specific human medical questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to discover remedies for all kinds of circumstances, like Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children. Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children Clinical Trials and other clinical trials allow for volunteers to have health treatment alternatives before they are available to the general public. Many times the test subjects obtain treatment for without cost, and occasionally they are paid for their time. Sometimes there is a cost for a Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children clinical trial. Subjects oftentimes recieve the most effective healthcare possible for their Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children condition. Hazards are a reality, however, and could include additional or frequent doctor visits, healthcare dangers (perhaps life-threatening), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children  Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children
Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children
For Condition: Learning Disorders,Dyslexia
Status: Recruiting
Sponsor(s): National Institute of Child Health and Human Development (NICHD) ,
Synopsis: This project is evaluating programs to improve reading and writing skills in children who have or are at risk for having reading disabilities. The project focuses on children who are at-risk for low achievement in school and on children with dyslexia.
Details: This study is part of a larger project to investigate the biological and educational constraints operating in children with learning disabilities, with a focus on treatment and links between assessment and treatment. The project evaluates prevention and treatment of reading and writing disabilities, the genetic contribution to subtypes of dyslexia, the relationship between brain variables and dyslexia, and the brain's response to treatment for dyslexia. Genetic and brain imaging studies occur throughout the project. During Year 1, at-risk readers in first grade were targeted for an intervention for mapping spoken words onto written words. These students were compared to a control group. During Year 2, the faster responders (those who reached grade level) and the slower responders (those who were not yet at grade level) from Year 1 were compared. Slower responders received additional treatment and comparisons were made again at the end of the year. The additional treatment was also studied in Spanish-speaking students in first grade. During Year 3, another group of at-risk, poor readers in second grade were randomized to either word decoding treatment, comprehension treatment, a combined word decoding and comprehension treatment, or a control treatment. During Year 4, readers at risk for failing state standards in reading (decoding) participated in an extended day program providing comprehensive reading instruction. The students were compared to a control group. During Year 5, all students grades 4 to 9 took a battery of morphological, reading, and writing tests. The testing was administered throughout an entire school system. During Year 6, older students with dyslexia were randomly assigned to phonological or morphological reading training. Students were then compared on pre- and post-test behavioral measures and brain activation results. During Year 7, students with dyslexia were randomly assigned to an orthographic or morphological treatment for spelling. Students underwent brain imaging before and after the intervention. Behavioral and brain activation measures were also assessed. During Year 8, students with dyslexia underwent attention or fluency training and writing training with and without attentional bridges. Only behavioral measures were collected. Recruitment of families for the family genetics study is ongoing. Recruitment for the brain imaging-treatment studies will begin in 2004 when installation of new brain imaging equipment is complete.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Single Blind, Active Control, Factorial Assignment, Efficacy Study
Minimum Age/Maximum Age: 6 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria - Student in grades 1 to 9 - Underachieving in reading and writing - English as first language Exclusion Criteria - Mental retardation - Developmental disability such as autism or pervasive developmental disorder - Brain damage or disease affecting brain function - Severe language or psychiatric disorder
Total Enrollment: 2500
Location and Contact Information:
Overall Study Official:
VirginiaBerninger, Principal Investigator, University of Washington
University of Washington *Recruiting*
Seattle, Washington,
United States
Recruiting Jennifer Thomson
Additional Information:
Study ID Numbers: 2P50HD33812-6;
Study Start Date: October 1996
Record last reviewed: November 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00061412
Other Dyslexia Studies:
1. Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children
Related Studies:
Other Dyslexia Clinical Trials
Other Washington Clinical Trials
Other Seattle Clinical Trials
Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children
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