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Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer Clinical Trials Resources presented on Clinical Trials Search is not meant to be a substitute for proven health advice, calls or treatment with a real medical. We aren't mDs. Always consult your doctor on Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer Clinical research trials and Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer healthcare trials take place in a lot of of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectiveness of new does drugs. The function of the studies / projects is to figure out specific human medical questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to find cures for all varieties of conditions, like Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer. Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer Clinical Trials and other clinical trials allow volunteers to access health treatment options before they are available to the masses. Many times the subjects receive professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer clinical trial. Human subjects often obtain the finest healthcare possible for their Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer condition. Hazards are a reality, nevertheless, and might include additional or frequent dr. calls, health hazards (potentially life-jeopardizing), and/or the treatment being uneffective. Trials are federally regulated with stern guidelines to protect clinical trials patients.
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Home > "C" Clinical Trials Conditions > Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer  Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer
Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer
For Condition: adult malignant ependymoma,Adult Medulloblastoma
Status: Recruiting
Sponsor(s): Eastern Cooperative Oncology Group , National Cancer Institute (NCI),Southwest Oncology Group
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug and combining chemotherapy with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by radiation therapy in treating adult patients with brain cancer.
Details: OBJECTIVES: - Determine the complete and partial response rate of patients with adult medulloblastoma, primitive neuroectodermal tumor, or disseminated ependymoma treated with preradiation combination chemotherapy. - Determine the progression free survival and overall survival of these adult patients treated with combination chemotherapy followed by craniospinal radiation. - Determine the toxic effects associated with this treatment in these patients. OUTLINE: Patients receive cisplatin IV over 6 hours, etoposide IV, and vincristine IV over 1-2 minutes on day 1; etoposide IV and cyclophosphamide IV over 1-2 hours on days 2-3; filgrastim (G-CSF) subcutaneously (SC) on days 4-13; and vincristine IV over 1-2 minutes on day 15. Treatment repeats every 42 days for up to 3 courses in the absence of disease progression or unacceptable toxicity. Within 4-6 weeks after the last chemotherapy course, patients undergo radiotherapy 5 days a week for 6 to 7 weeks. Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually for 5-10 years. PROJECTED ACCRUAL: A total of 33 patients will be accrued for this study within 3 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed central nervous system cancer including: - Medulloblastoma with either local residual disease of greater than 1 cm^2 on MRI following resection or evidence of metastases (M1-4) - Other primitive neuroectodermal tumors - Ependymoma with evidence of subarachnoid metastases - Must have less than 1 cm of midline shift or no acute elevated intercranial pressure PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - ECOG 0-2 Life expectancy: - Not specified Hematopoietic: - WBC greater than 4,000/mm^3 - Platelet count greater than 125,000/mm^3 - Hemoglobin greater than 10 g/dL - No preexisting hematologic condition that would increase toxicity or limit ability to comply with evaluations and follow-up Hepatic: - Bilirubin less than 2 times upper limit of normal (ULN) - SGOT less than 2 times ULN - Alkaline phosphatase less than 2 times ULN - No preexisting hepatic condition that would increase toxicity or limit ability to comply with evaluations and follow-up Renal: - Creatinine greater than 70 mL/min - No preexisting renal condition that would increase toxicity or limit ability to comply with evaluations and follow-up Pulmonary: - No history of significant pulmonary disease or, if there is preexisting pulmonary disease, then DLCO greater than 60% of predicted - No preexisting pulmonary condition that would increase toxicity or limit ability to comply with evaluations and follow-up Other: - No preexisting psychiatric condition that would increase toxicity or limit ability to comply with evaluations and follow-up - No prior or concurrent malignancies within the past 5 years except curatively treated carcinoma in situ of the cervix or basal cell or squamous cell skin cancer - Not pregnant or nursing - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - No prior chemotherapy Endocrine therapy: - No increasing doses of steroids for intracranial disease within 3 days of registration Radiotherapy: - No prior radiotherapy Surgery: - 10-28 days since prior surgical resection OR - At least 5 days since prior biopsy
Total Enrollment:
Location and Contact Information:
Overall Study Official:
PaulMoots, Study Chair, Vanderbilt-Ingram Cancer Center
CCOP - Cedar Rapids Oncology Project *Recruiting*
Cedar Rapids, Iowa, 52403-1206
United States
Recruiting Martin Wiesenfeld 319-363-8303
CCOP - Wichita *Recruiting*
Wichita, Kansas, 67214-3882
United States
Recruiting Shaker Dakhil 316-268-5784
Robert H. Lurie Comprehensive Cancer Center at Northwestern University *Recruiting*
Chicago, Illinois, 60611
United States
Recruiting Al Benson 312-695-1382
H. Lee Moffitt Cancer Center and Research Institute *Recruiting*
Tampa, Florida, 33612-9497
United States
Recruiting Cancer Answers 813-972-4673
CCOP - Iowa Oncology Research Association *Recruiting*
Des Moines, Iowa, 50309-1016
United States
Recruiting Roscoe Morton 515-244-7586
CCOP - Metro-Minnesota *Recruiting*
St. Louis Park, Minnesota, 55416
United States
Recruiting Patrick Flynn 952-993-15175
Medical College of Wisconsin Cancer Center *Recruiting*
Milwaukee, Wisconsin, 53226-3596
United States
Recruiting David Vesole 414-805-4646
Veterans Affairs Medical Center - Lakeside Chicago *Recruiting*
Chicago, Illinois, 60611-4494
United States
Recruiting Timothy Kuzel 312-469-3748
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center *Recruiting*
Nashville, Tennessee, 37232-6307
United States
Recruiting David Johnson 615-343-9454
Norris Cotton Cancer Center at Dartmouth Medical School *Recruiting*
Lebanon, New Hampshire, 03756-0002
United States
Recruiting Camilo Fadul 603-650-6312
CCOP - Kalamazoo *Recruiting*
Kalamazoo, Michigan, 49007-3731
United States
Recruiting Raymond Lord 269-373-7488
CCOP - Carle Cancer Center *Recruiting*
Urbana, Illinois, 61801
United States
Recruiting Kendrith Rowland 217-383-4083
CCOP - Marshfield Clinic Research Foundation *Recruiting*
Marshfield, Wisconsin, 54449
United States
Recruiting Tarit Banerjee 715-387-5134
Additional Information:
Study ID Numbers: CDR0000066256; ECOG-4397,SWOG-E4397
Study Start Date:
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003309
Other Adult Malignant Ependymoma Studies:
1. Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer
2. Carmustine in Treating Patients With Recurrent Malignant Glioma
3. Carmustine Followed By Surgery in Treating Patients With Recurrent Supratentorial Malignant Glioma or Metastatic Brain Neoplasm
4. Etoposide Plus Cisplatin in Treating Patients With Recurrent Ependymomas
Related Studies:
Other adult malignant ependymoma Clinical Trials
Other Minnesota Clinical Trials
Other St. Louis Park Clinical Trials
Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer
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