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Cocaine-Metyrapone Interaction Study - 1



Cocaine-Metyrapone Interaction Study - 1

For Condition: Infusions, Intravenous,Cocaine-Related Disorders
Status: No longer recruiting
Sponsor(s): National Institute on Drug Abuse (NIDA) , VA Medical Center-Cincinnati
Synopsis: This study will be to examine the safety of 2 consecutive days of dosing in subjects who may use cocaine concurrently.
Details: To evaluate the safety of metyrapone (MRP) for using in an outpatient study in which participants would be given 2 750 mg doses of MRP per week. Secondary study goals are to evaluate the possible efficacy of MRP as a treatment for cocaine dependence and to compare 3 factors hypothesized to induce cocaine craving: cocaine cues, stress, and cocaine itself. This study will utilize a Double Blind, placebo-controlled crossover design with 3 factors: 1) medication 2) relapse trigger and 3) infusion for an 11 day in-patient treatment.
Eligibility:
Study Type:  Interventional, Treatment, Double-Blind, Placebo Control, Crossover Assignment
Minimum Age/Maximum Age: 18 Years/45 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: Male or Females between 18 and 45 yrs of age; cocaine dependence according to DSM-4; females of child-bearing potential must test non-pregnant and use adequate birth control; be able to provide consent, comply with protocol requirements and try to complete all study treatments. Exclusion Criteria: Additional criteria available during screening at the site.
Total Enrollment: 12

Location and Contact Information:

Overall Study Official:
TheresaWinhusen,  Principal Investigator,  VA Medical Center-Cincinnati

Cincinnati VA Medical Center
Cincinnati,  Ohio,  45220
United States
 


Additional Information:
Study ID Numbers:  NIDA-CTO-0006-1; 
Study Start Date: November 2001
Record last reviewed: August 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00033098

Other Infusions, Intravenous Studies:
1. Effects of Phenytoin on Cocaine Use in Humans - 2

2. To Study Predictive Values of M-CPP and Fenfluamine in Cocaine Addicts - 3

3. Effect of Nefazodone on Relapse in Females with Cocaine Abuse - 10

4. Naltrexone as an Adjunct in Alcoholic Cocaine Dependent Patients - 4

5. Drug Interaction Study with NS2359 and Cocaine in Cocaine Experienced Volunteers - 1

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