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CHP677: I-Metaiodobenzylguanidine (I-MIBG) therapy for refractory neuroblastoma: a Phase II study



CHP677: I-Metaiodobenzylguanidine (I-MIBG) therapy for refractory neuroblastoma: a Phase II study

For Condition: Neuroblastoma
Status: Recruiting
Sponsor(s): National Center for Research Resources (NCRR) ,
Synopsis: 131I-metaiodobenzylguanidine (131I-MIBG) is a norepinephrine analog that concentrates in adrenergic tissue and therefore holds promise for cell-specific treatment of neuroblastoma. This is a dual institution, Phase II study of 131I-MIBG administered at the previously defined maximum practical dose of 18 mCi/kg to children with relapsed or refractory neuroblastoma.
Details:
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Inclusion criteria: Refractory neuroblastoma with original diagnosis based on tumor histopathology or elevated urine VMA with typical tumor cells in the bone marrow.
Total Enrollment: 

Location and Contact Information:

Children's Hospital of Philadelphia *Recruiting*
Philadelphia,  Pennsylvania,  19104
United States
Recruiting John  Maris 215-590-5242


Additional Information:
Study ID Numbers:
  NCRR-M01RR00240-1748; 
Study Start Date: 
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00013806

Other Neuroblastoma Studies:
1. A Phase II Trial of All-Trans-Retinoic Acid in Combination with Interferon-Alpha 2a in Children with Recurrent Neuroblastoma or Wilms' Tumor

2. Neuroblastoma Vaccine for Treatment of High-Risk Neuroblastoma After Chemotherapy

3. Using Gene Modified Neuroblastoma Cells for the Treatment of Relapsed/Refractory Neuroblastoma.

4. Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

5. Irinotecan in Treating Children With Refractory Solid Tumors

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CHP677: I-Metaiodobenzylguanidine (I-MIBG) therapy for refractory neuroblastoma: a Phase II study

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