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Cholesterol Reduction in Seniors Program (CRISP) Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on Cholesterol Reduction in Seniors Program (CRISP) conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Cholesterol Reduction in Seniors Program (CRISP) Clinical research trials and Cholesterol Reduction in Seniors Program (CRISP) medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including Cholesterol Reduction in Seniors Program (CRISP). Cholesterol Reduction in Seniors Program (CRISP) Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Cholesterol Reduction in Seniors Program (CRISP) clinical trial. Participants oftentimes recieve the finest healthcare available for their Cholesterol Reduction in Seniors Program (CRISP) condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Cholesterol Reduction in Seniors Program (CRISP)  Cholesterol Reduction in Seniors Program (CRISP)
Cholesterol Reduction in Seniors Program (CRISP)
For Condition: Atherosclerosis,Cardiovascular Diseases,Coronary Disease,Heart Diseases,Hypercholesterolemia,Myocardial Ischemia
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To conduct a pilot study to determine whether lowering elevated serum cholesterol levels with 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG CoA) reductase inhibitors reduced mortality due to the sequelae of atherosclerotic cardiovascular disease in older men and women.
Details: BACKGROUND: Circulating levels of cholesterol, specifically cholesterol associated with the low-density lipoprotein (LDL) fraction, have been established by observational epidemiologic studies and by metabolic, pathologic, genetic studies in humans and selected animal models, and by randomized clinical trials as a major etiologic factor in coronary heart disease. The ratio between the percent reduction in coronary heart disease incidence and the percent reduction in cholesterol levels associated with treatment in randomized trials, approximately 2:1, is almost exactly that predicted by numerous observational epidemiologic studies of this relationship. However, the clinical trials demonstrating that lowering LDL-cholesterol levels reduces subsequent incidence of coronary heart disease events have been confined by and large to middle-aged men with hypercholesterolemia as in the Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT) or to men with established coronary heart disease as in the Coronary Drug Project (CDP). Experimental confirmation that cholesterol-lowering treatment is worthwhile after as well as before age 60 is lacking. Thus, although the guidelines issued in October 1987 by the National Cholesterol Education Program's (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults did not discriminate explicitly by age, the absence of direct evidence of efficacy led them to allow room for physician judgment in applying their recommendations to older patients. This uncertainty in the application of the NCEP guidelines to older men and women is a matter of considerable consequence to the public health. Epidemiologic studies suggest that the prognostic power of cholesterol levels diminishes with advancing age. Subdivision of the participants in several cohort studies into those above or below age 50 at entry shows that the increment in coronary heart disease risk per increment in total or LDL cholesterol level is nearly always substantially lower in the older group. In the Framingham Heart Study, the study with the most follow-up data beyond age 60, a 0.5 percent increment in the coronary heart disease incidence rate was estimated per 1 mg/dl increment in plasma cholesterol level -- about 60 percent of the increment seen in middle-aged men and women. However, the absolute numbers of potentially preventable coronary heart disease deaths, 80 percent of which occur after age 65, and myocardial infarctions attributable to high plasma cholesterol levels in Framingham and other observational studies appear to increase with increasing age. Previous clinical trials of cholesterol-lowering drugs have been weakened by their limited efficacy and acceptability to patients. In older patients, the administration of cholesterol-lowering drugs may be further complicated by interactions with drugs taken for other more pressing conditions. However, since the Food and Drug Administration approved the HMG CoA reductase inhibitor, lovastatin, in September 1987, the agent has been efficacious and well-tolerated by patients of all ages, and has been used increasingly widely. In 1986, an ad hoc committee of the National Heart, Lung, and Blood Institute's Atherosclerosis, Hypertension, and Lipid Metabolism Advisory Committee (AHLMAC) recommended a randomized clinical trial of cholesterol-lowering using an HMG CoA reductase inhibitor in the elderly. The recommendation was endorsed by the full AHLMAC and approved by the National Heart, Lung, and Blood Advisory Council (NHLBAC) in May 1987. However, due to the high cost of such a trial and concerns about feasibility, an initiative for a two-year pilot study at five clinical centers was developed and approved by the NHLBAC in September 1988. The Request for Applications was released in February 1989 and awards made in July 1990. DESIGN NARRATIVE: There were five clinical centers and a coordinating center in the pilot study. There were four pre-randomization visits at four to six week intervals. Subjects were eligible for inclusion if their LDL cholesterol levels remained above 120 mg/dl after the introduction of the American Heart Association Step 1 Diet at Visit 2. Subjects were randomized to diet plus a low dosage of lovastatin (20 mg), diet plus a high dosage of lovastatin (40 mg), or to diet plus a placebo. End points were changes in blood lipid levels. Data on other blood chemistry values, as well as quality-of-life measures and coronary heart disease morbidity and mortality, were also collected. LDL cholesterol levels were measured at clinic visits six and twelve weeks after randomization and at twelve week intervals thereafter. Serum alanine aminotransferase levels were measured at six week intervals to determine liver function and slit lamp exams were performed before and after study medication to detect lenticular opacities. Subjects were followed for a minimum of six months and a maximum of fifteen months.
Eligibility:
Study Type: Interventional, Prevention, Randomized
Minimum Age/Maximum Age: 65 Years/
Genders: Both
Protocol Entry Criteria: Men and women, ages 65 and older, with elevated low-density lipoprotein cholesterol levels between 159 and 221 mg/dl at entry.
Total Enrollment:
Location and Contact Information:
Overall Study Official:
WilliamApplegate, , University of Tennessee
Additional Information:
Study ID Numbers: 66;
Study Start Date: July 1990
Record last reviewed: June 1992
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000477
Other Atherosclerosis Studies:
1. Genetic Determinants:Low HDL, High Triglycerides, Obesity
2. National Growth and Health Study (NGHS)
3. Visceral Adiposity and CVD Risk in Women
4. Interactions Between HIV Protease Inhibitors and Calcium Channel Blockers
5. Physical Activity and Cardiovascular Risk in Black Girls
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Cholesterol Reduction in Seniors Program (CRISP)
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