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Home > "C" Clinical Trials Conditions > Characteristics of Idiopathic Familial Voice Disorders  Characteristics of Idiopathic Familial Voice Disorders
Characteristics of Idiopathic Familial Voice Disorders
For Condition: Laryngeal Disease,Spastic Dysphonia,Voice Disorder
Status: Recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: The purpose the study is to determine the genetic causes of specific voice disorders that run in families. Researchers are particularly interested in two conditions; 1. Spasmodic dysphonia 2. Vocal fold paralysis Familial vocal fold paralysis can be a life-threatening disorder that can cause difficulty with vocal fold movement for breathing and voice and sometimes for swallowing. Studies are ongoing at the NIH to better understand the pathophysiology and to relate it to the genetic pattern of inheritance. Families are being recruited to participate in these studies and are being provided with further information on the disorder and genetic counseling if desired. Physician referral is requested for affected members of families with vocal fold paralysis of an unknown cause occurring over at least 2 generations. All travel, lodging, examination and counseling costs are covered for both affected and unaffected members of a family. Examinations include: voice, laryngeal, neurological, electrodiagnostic testing, genetic counseling, and radiological studies.
Details: The purpose of this protocol was to determine if there was evidence of a genetic risk factor involved in spasmodic dysphonia. Families with multiple members affected with spasmodic dysphonia were ascertained. The following hypotheses are being addressed: 1. Spasmodic dysphonia rarely occurs in families and is unrelated to idiopathic torsion dystonia. 2. Families with spasmodic dysphonia have occurrences of other laryngeal control disorders. 3. Familial vocal fold paralysis is associated with neuropathy or neuronopathies.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Symptoms present during speech and not apparent at rest, Symptoms less evident during whisper, singing or falsetto. Symptoms become worse with prolonged speaking, practice or anxiety. Reflexive and emotional aspects of voice function are unaffected, such as coughing, laughter or crying. EXCLUSION CRITERIA: Any patient with a history of airway obstruction will be excluded from the study. Structural abnormalities affecting the larynx such as vocal fold nodules, polyps, carcinoma, cysts, contact ulcers, or inflammation (laryngitis). Reduction in vocal fold movement range during non-speech tasks such as whistling which would suggest either paralysis or paresis, joint abnormality or neoplasm. No smokers or tobacco users will be included in the study. Subjects with history of a psychiatric disorder, under the care of a psychiatrist, or on medications for treatment of a psychiatric disorder will be excluded from the study. Examples of psychiatric disorders to be excluded are: somatoform disorders, conversion disorders, currently under treatment for a major depression, or a history of schizophrenia or a bipolar disorder. However, a history of a previous episode of a minor reactive depression would not exclude a person from participation.
Total Enrollment: 220
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 960089; 96-N-0089
Study Start Date: May 22, 1996
Record last reviewed: May 6, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001552
Other Laryngeal Disease Studies:
1. Characteristics of Idiopathic Familial Voice Disorders
Related Studies:
Other Laryngeal Disease Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Characteristics of Idiopathic Familial Voice Disorders
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