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Home > "C" Clinical Trials Conditions > Central Obesity and Disease Risk in Japanese Americans  Central Obesity and Disease Risk in Japanese Americans
Central Obesity and Disease Risk in Japanese Americans
For Condition: Insulin Resistance,Heart Diseases,Hypertension,Diabetes Mellitus, non-insulin dependent,Metabolic Syndrome X,Atherosclerosis,Obesity,Diabetes Mellitus,Hyperinsulinism,Coronary Arteriosclerosis,Cardiovascular Diseases
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To conduct a longitudinal study of central obesity and related risk factors found to be associated with hypertension and atherosclerotic cardiovascular disease (ASCVD) in a previously-examined cross-sectional cohort of second-generation Japanese Americans and in a newly-recruited cohort of third generation Japanese Americans.
Details: BACKGROUND: The study was conducted in response to a program announcment issued in 1991 on obesity and tests the hypothesis that atherosclerotic cardiovascular disease (ASCVD), hypertension, and/or non-insulin dependent diabetes mellitus (NIDDM) develop in Japanese Americans when there is a truncal pattern of weight gain (central adiposity), which is in turn accompanied by insulin resistance, hyperinsulinemia, and lipid abnormalities. This cluster of abnormalities has been called 'Syndrome X'. It is postulated that 'Syndrome X' develops in Japanese Americans in response to environmental (behavioral) factors, many of which reflect 'westernization' in this ethnic group. The research plan focuses upon the relationship between central obesity and metabolic changes and disease outcomes associated with 'Syndrome X' along with the behavioral variables that potential risk factors for the development of this cluster of abnormalities. DESIGN NARRATIVE: The cohort was re-examined for diabetes, hypertension, coronary heart, disease, peripheral vascular disease, and a number of potential coronary heart disease risk factors including medical history, health practice, social history, diet, glycosylated hemoglobin, insulin, proinsulin, c-peptide, glucose, anthrometric measurements, lipids, and computed tomography on the thorax, abdomen, and thigh.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: 45 Years/74 Years
Genders: Both
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Overall Study Official:
WilfredFujimoto, , University of Washington
Additional Information:
Study ID Numbers: 4252;
Study Start Date: February 1993
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005365
Other Insulin Resistance Studies:
1. Cardiovascular Disease Knowledge/Morbidity--Socioeconomic Cohort Outcomes
2. Improving Hypertension Control in the Inner City
3. APEX: Adiposity Prevention by Exercise in Black Girls
4. Speech Characteristics in Coronary Heart Disease
5. Family Blood Pressure Program - HyperGEN
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Central Obesity and Disease Risk in Japanese Americans
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