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Home > "C" Clinical Trials Conditions > Cell Studies of Parkinson's Disease  Cell Studies of Parkinson's Disease
Cell Studies of Parkinson's Disease
For Condition:
Status: Recruiting
Sponsor(s): National Human Genome Research Institute (NHGRI) ,
Synopsis: This study will examine and compare blood samples from healthy volunteers and patients with Parkinson's disease to identify abnormalities associated with Parkinson's disease. Disease symptoms include slowness of movement, hand or leg shaking, and stiffness. Some patients have difficulty with balance. Information from this study may provide information on how Parkinson's disease affects the brain and body, and may help lead to a test for earlier diagnosis. Healthy volunteers and patients with Parkinson's disease who are 18 years of age or older may enroll in this study. Participants will undergo the following procedures: - Physical examination, including evaluation of strength, feeling, coordination, and balance - Blood drawing: 150 milliliters (about 10 tablespoons) of blood will be drawn - Personal and family medical history - Consent to access medical records for research purposes Blood samples will be examined for: - Genetic analysis - Study of specific proteins and lipids - Study of mitochondria (parts of cells that make energy)
Details: This study wants to focus on mitochondrial defects associated with Parkinson's disease (PD) and how they relate to alpha-synuclein (SNCA) expression and function. Individuals from families with inherited Parkinson's disease (affected and at risk members), as well as normal individuals, will be enrolled. All subjects will be asked to provide blood samples in order to study bioenergetic function in mitochondria from their platelets. These studies will include genotyping and determination of polymorphisms in the subjects' mitochondrial DNA (mtDNA) in order to delineate any significant abnormality that may be associated with a particular group. Cardiolipin levels will be obtained fee for service at Lipomics. Basic respirometry, enzyme activity, and somatic cell hybridization will be performed in the PI's lab. Protein analysis will be performed in the proteomics facility at NIMH.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Decisionally impaired subjects will be enrolled. EXCLUSION CRITERIA: No person under the age of 18 will be enrolled in this study. This is due to the fact that, except for very rare occasions, Parkinson's disease affects only adults.
Total Enrollment: 150
Location and Contact Information:
National Human Genome Research Institute (NHGRI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 040092; 04-HG-0092
Study Start Date: January 14, 2004
Record last reviewed: January 13, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00076505
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Cell Studies of Parkinson's Disease
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