|
Celebrex for Pain Relief After Oral Surgery Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about Celebrex for Pain Relief After Oral Surgery conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Celebrex for Pain Relief After Oral Surgery Clinical research trials and Celebrex for Pain Relief After Oral Surgery health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like Celebrex for Pain Relief After Oral Surgery. Celebrex for Pain Relief After Oral Surgery Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a Celebrex for Pain Relief After Oral Surgery clinical trial. Human subjects often get the best healthcare available for their Celebrex for Pain Relief After Oral Surgery condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.
|
|
|
|
|
|
|
Home > "C" Clinical Trials Conditions > Celebrex for Pain Relief After Oral Surgery  Celebrex for Pain Relief After Oral Surgery
Celebrex for Pain Relief After Oral Surgery
For Condition: Facial Pain
Status: Completed
Sponsor(s): National Institute of Dental and Craniofacial Research (NIDCR) ,
Synopsis: This study will evaluate the effects of the new anti-inflammatory drug, Celebrex, on relieving pain after oral surgery. It is also designed to assess the drug's selective inhibition of a chemical called cyclooxygenase-2 and not its closely related form, cyclooxygenase-1. This selective inhibition allows pain alleviation without the adverse side effects (e.g., bleeding and stomach upset) often associated with anti-inflammatory drugs. Healthy volunteers who require removal of their third molars are eligible for this study. Participants will have oral surgery for tooth extraction after receiving a local anesthetic (lidocaine) in the mouth and a sedative (midazolam) through an arm vein. On the evening before and 1 hour before surgery, patients will be given a dose of either the standard anti-inflammatory drug ibuprofen (Advil, Nuprin, Motrin), or Celebrex, or a placebo (a pill with no active ingredient). After surgery, a small piece of tubing will be placed in each extraction site and tied to an adjacent tooth to hold it in place. Samples will be collected from the tubing to measure chemicals involved in pain and inflammation. Patients will stay in the clinic for up to 6 hours after surgery while the anesthetic wears off and will complete pain questionnaires. During that time, they may receive acetaminophen plus codeine (Tylenol 3), if needed, for pain. The tubing then will be removed and the patient discharged with standard pain medication.
Details: Prostanoids are mediators that have been implicated in all stages of inflammation. The inhibition of prostanoid synthesis by NSAIDs forms the basis of their therapeutic as well as side effects. NSAIDs directly inhibit cyclooxygenase [COX], which leads to reduction of prostaglandin synthesis and also to gastric erosions, inhibition of platelet aggregation and nephrotoxicity. The identification of the two isoforms of COX lead to the hypothesis that COX-2 is responsible for the production of prostaglandins following tissue injury, while COX-1 is involved in normal homeostasis. The selective COX-2 inhibitors are believed to be efficacious anti-inflammatory drugs devoid of the side effects associated with the inhibition of COX-1. However, the selectivity of these drugs has only been demonstrated in vitro and ex vivo, which may not be a reliable indicator of the in vivo selectivity. The proposed study aims to evaluate the in vivo selectivity of celecoxib, a drug demonstrated to be a selective inhibitor of COX-2 in vitro in the oral surgery model of acute inflammation.
Eligibility:
Study Type: Interventional, Treatment, Safety/Efficacy
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Healthy volunteers between the ages of 18-65 years. Patients will be eligible for this study if the two mandibular molars are classified as partial or full bony impactions. EXCLUSION CRITERIA: Patients who are allergic to sulfa-drugs. Patients who have had asthma, hives or an allergic reaction to aspirin, ibuprofen or any similar drugs. Patients with gastrointestinal ulcers or a history of gastrointestinal bleeding. Patients who are pregnant or nursing. Patients of infection or inflammation [pericoronitis] at either extraction site. Patients with severe kidney disease. Patients who are taking any of the following drugs: anti-depressants, diuretics, aspirin on a near daily basis, coumadin or other blood thinners. Patients who are taking drugs known to inhibit P450 2C9 and drugs metabolized by P450 2D6.
Total Enrollment: 120
Location and Contact Information:
National Institute of Dental And Craniofacial Research (NIDCR)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 000027; 00-D-0027
Study Start Date: December 3, 1999
Record last reviewed: February 18, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006299
Other Facial Pain Studies:
1. Neurotropin to Treat Acute Dental and Chronic Neural Pain
2. Celebrex for Pain Relief After Oral Surgery
3. Capsaicin to Control Pain Following Third Molar Extraction
4. Diagnosis and Evaluation of Patients Needing Third Molar (Wisdom Tooth) Extraction and Patients with Chronic Facial Pain
Related Studies:
Other Facial Pain Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Celebrex for Pain Relief After Oral Surgery
|
|
|
|
|
|
|
|
