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Home > "C" Clinical Trials Conditions > Cardiopulmonary Effects of Particulate Exposure  Cardiopulmonary Effects of Particulate Exposure
Cardiopulmonary Effects of Particulate Exposure
For Condition: Cardiac Diseases,Bronchitis,Respiratory Tract Diseases
Status: Recruiting
Sponsor(s): National Institute of Environmental Health Sciences (NIEHS) ,
Synopsis: The aim of this study is to assess cardiac rate and respiratory responses and rhythm after workplace exposure to combustion particulates. A repeated measurement study is being performed on acute boilermakers (apprentices and journeymen). A stratified analysis is then done on those with and without chronic bronchitis, after adjustment for relevant covariates.
Details: Population-based epidemiologic studies of communities in the United States have revealed a consistent association between ambient particulate air pollution and increases in morbidity and mortality. The observed increases result from both respiratory and cardiovascular diseases. Similar associations have been observed for rates of hospital admissions for respiratory and cardiovascular diseases for subjects over age 65. These ambient exposures are to low levels of particulates, many times lower than occupational exposures faced by workers in a variety of industries, including manufacturing, construction, transportation and electric-power generation. The objective of this proposal is to investigate the role of occupational exposure to particulates in the development of respiratory and cardiac responses in boilermakers. We will employ a detailed, continuous-exposure assessment to PM2.5 with repeated measures of biologic and physiologic markers of response. Specific hypotheses to be tested will include: (1) occupational exposure to fuel-oil ash particulates induce airway inflammation as reflected in increased expired NO, and airflow obstruction as reflected in decreases in peak flow (PEFR) and FEV1; (2) particulate exposure will result in acute changes in cardiovascular function, as reflected in changes in heart rate, heart-rate variability and blood pressure; (3) particulate exposures result in increased serum fibrinogen levels, a known risk factor for cardiovascular disease; and (4) chronic bronchitis predisposes particulate-exposed workers to changes in cardiac function. The results of this study will have important implications for preventive efforts aimed at reducing morbidity and mortality from occupational exposure to respirable particulates.
Eligibility:
Study Type: Observational, Natural History, Longitudinal, Defined Population, Prospective Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Adults; Over 18; Boilermakers
Total Enrollment:
Location and Contact Information:
Harvard School of Public Health *Recruiting*
Boston, Massachusetts, 02115
United States
Recruiting David Christiani 617-432-1260
Additional Information:
Study ID Numbers: 9860-CP-001;
Study Start Date: March 1999
Record last reviewed: March 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00011310
Other Bronchitis Studies:
1. Honolulu Heart Program
2. Cardiopulmonary Effects of Particulate Exposure
3. Medication Adherence in COPD--A Self-Regulation Study
Related Studies:
Other Bronchitis Clinical Trials
Other Massachusetts Clinical Trials
Other Boston Clinical Trials
Cardiopulmonary Effects of Particulate Exposure
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