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Home > "C" Clinical Trials Conditions > Campath-1H and Allogeneic Blood Stem Cell Transplantation for Lymphoid Malignancies  Campath-1H and Allogeneic Blood Stem Cell Transplantation for Lymphoid Malignancies
Campath-1H and Allogeneic Blood Stem Cell Transplantation for Lymphoid Malignancies
For Condition: Leukemia, Lymphocytic, Acute,Lymphoma, Low-Grade,Lymphoma, T-Cell,Leukemia, Lymphocytic, Chronic,Lymphoma, B-Cell
Status: Recruiting
Sponsor(s): M.D. Anderson Cancer Center ,
Synopsis: High dose chemotherapy followed by transplantation of allogeneic hematopoietic stem cell with the use of Campath-1h, a monoclonal antibody that have a synergistic effect to chemotherapy with minimal toxicity. In addition Campath-1H can improve engraftment of donor cells through its immunosuppressive properties.
Details:
Eligibility:
Study Type: Interventional, Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 15 Years/60 Years
Genders: Both
Protocol Entry Criteria: - Patients with CLL, ALL, low grade Lymphoma, B and T cell Lymphoma of the intermediate and high grade (if not eligible for autologous transplant) CD52 expression of >20% by flow cytometry. - Patients in relapse after conventional treatment. - Patients with an HLA-identical or one-antigen mismatched sibling, or matched unrelated donor. - Patients previously exposed to Campath-1H treatment response. Patient must be at least 2 months or later from the last dose of Campath-1H.
Total Enrollment: 142
Location and Contact Information:
MDAnderson Cancer Center *Recruiting*
Houston, Texas, 77030
United States
Recruiting Donna Griffith 713-792-4230
Additional Information:
Study ID Numbers: ID99-410;
Study Start Date: April 2001
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00038883
Other Lymphoma, T-Cell Studies:
1. Campath-1H and Allogeneic Blood Stem Cell Transplantation for Lymphoid Malignancies
2. Phase II Study Of Roferon and Accutane For Patients With T-Cell Malignancies
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Campath-1H and Allogeneic Blood Stem Cell Transplantation for Lymphoid Malignancies
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