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Home > "B" Clinical Trials Conditions > Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children  Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children
For Condition: Autoimmune Disease,Congenital Adrenal Hyperplasia,Healthy,Mental Disorder Diagnosed in Childhood,Neurologic Manifestations
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. MRI use as the name implies, magnetism to create pictures with excellent anatomical resolution. Functional MRIs are diagnostic tests that allow doctors to not only view anatomy, but physiology and function. It is for these reasons that MRIs are excellent methods for studying the brain. In this study, researchers will use MRIs to assess brain anatomy and function in normal volunteers and patients with a variety of childhood onset psychiatric disorders. The disorders include attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, multidimensional impairment syndrome, obsessive compulsive disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS), stuttering, Sydenham's chorea, and Tourette's syndrome. Results of the MRIs showing the anatomy of the brain and brain function will be compared across age, sex (gender), and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations.
Details: Structural magnetic resonance imaging (MRI), with its lack of ionizing radiation and excellent anatomical resolution, provides unprecedented opportunity to quantify the anatomy of the developing brain. Functional MRI allows in vivo assessment of pediatric brain physiology. Diffusion tensor imaging allows mapping of white matter tracts. Magnetic resonance spectroscopy allows metabolic assessment. Cerebral MRI will be used to assess brain anatomy and function in normal volunteers and subjects with a variety of childhood onset psychiatric disorders including attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, multidimensional impairment syndrome, obsessive compulsive disorder. Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection (PANDAS), stuttering, Sydenham's chorea, and Tourette's Syndrome. Quantitative measures of brain structure and function will be compared across age, gender, and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations. Both singleton and twin subjects will be assessed.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Normal controls will be recruited from the community. Clinical subjects to be scanned will have met screening and diagnositc criteria set forth by protocols pertaining to specific diagnosis. Any patient with cognitive impairment over the age of 18 will require a durable-power-of-attorney. Competent patients who turn 18 should sign the consent themselves.
Total Enrollment: 3000
Location and Contact Information:
National Institute of Mental Health (NIMH) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 890006; 89-M-0006
Study Start Date: January 10, 1989
Record last reviewed: January 9, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001246
Other Mental Disorder Diagnosed In Childhood Studies:
1. Heterosexual HIV Transmission Study (HATS)
2. PET Scans in Normal Volunteers and Patients with Fabry Disease
3. Segmental Bronchoalveolar Lavage
4. Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes
5. Serotonin in Alcoholism
Related Studies:
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Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children
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