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Brain Imaging - Acupuncture and Osteoarthritis Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment by using a genuine medical doctor. We aren't mDs. Always confer with your doctor on Brain Imaging - Acupuncture and Osteoarthritis conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Brain Imaging - Acupuncture and Osteoarthritis Clinical research trials and Brain Imaging - Acupuncture and Osteoarthritis healthcare trials occur in a lot of of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new does drugs. The role of the studies / undertakings is to solve specific human healthcare questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to find treatments for all kinds of conditions, including Brain Imaging - Acupuncture and Osteoarthritis. Brain Imaging - Acupuncture and Osteoarthritis Clinical Trials and other clinical trials allow for volunteers to access health treatment choices before they are available to the general public. Many times the test subjects get treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a Brain Imaging - Acupuncture and Osteoarthritis clinical trial. Test subjects typically receive the most effective healthcare possible for their Brain Imaging - Acupuncture and Osteoarthritis condition. Risks are a reality, nonetheless, and could include extra or frequent dr. calls, health hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "B" Clinical Trials Conditions > Brain Imaging - Acupuncture and Osteoarthritis  Brain Imaging - Acupuncture and Osteoarthritis
Brain Imaging - Acupuncture and Osteoarthritis
For Condition: Osteoarthritis
Status: Not yet recruiting
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: The goal of this study is to use single photon emission computed tomography (SPECT) and functional magnetic resonance imaging (f-MRI) of the brain to study the response of both normal participants and participants with Osteoarthritis of the knee to acupuncture.
Details: Recent experimental studies in both animal and humans have begun to demonstrate some measureable physiologic effects that are associated with acupuncture, suggesting the possibility of a neurophysiologic explanation. In addition, brain research continues to uncover a complex set of endogenous neurologic control systems, such that it has become clear that the brain plays a major role in the modulation of pain perception and control. If acupuncture can be demonstrated to have a consistent effect on specific areas of the brain, it will become possible to explore the potential efficacy of acupuncture based on measurable neurophysiologic responses.
Eligibility:
Study Type: Interventional, Diagnostic, Randomized, Single Blind, Active Control, Crossover Assignment, Pharmacodynamics Study
Minimum Age/Maximum Age: 40 Years/
Genders: Both
Protocol Entry Criteria: Inclusion criteria: - Seen in an outpatient clinical setting - Have active knee OA of >6 months including Kellgren x-ray changes >2 from an x-ray report <12 months old or new x-ray interpretation - Moderate unilateral only pain (average >4/10 on a 0-10 likert scale) for more than 5 out of 7 days - Have the capacity to understand the requirements of the study and complete the baseline studies in a reasonable time frame, as determined by the interviewer Exclusion criteria: - Having had acupuncture before (must be acupuncture naïve) - Any history of claustrophobia that could affect the subject’s ability to tolerate the f-MRI study - Hip or ankle disease by history or exam severe enough to cause pain >2/10 daily - Bleeding disorder or current use of warfarin or heparin by patient history - Other primary causes of chronic knee pain, per the referring physician, including chondromalacia patella, torn meniscus or ligament injury.
Total Enrollment: 32
Location and Contact Information:
Overall Study Official:
JohnFarrar, Principal Investigator, University of Pennsylvania
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104-4283
United States
Andrew Newberg 215-662-3014
Additional Information:
Study ID Numbers: R21 AT000960-01A1;
Study Start Date: January 2004
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00070824
Other Osteoarthritis Studies:
1. Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
2. Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
3. A Study of Orthotic Shoe Inserts for Controlling Osteoarthritic Knee Pain
4. Muscle Strengthening Device for Knee Osteoarthritis
5. Patient Education in Rheumatoid Arthritis and Osteoarthritis
Related Studies:
Other Osteoarthritis Clinical Trials
Other Pennsylvania Clinical Trials
Other Philadelphia Clinical Trials
Brain Imaging - Acupuncture and Osteoarthritis
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