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Brain Blood Flow Studies of Language and Memory



Brain Blood Flow Studies of Language and Memory

For Condition: Cerebrovascular Disorder,Epilepsy
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive water (H215O) and PET scans to observe what areas of the brain are receiving more blood flow. This study is designed to use positron emission tomography (PET) with radioactive water (H215O) to determine the areas of the brain associated with memory and language. Patients participating in the study will be made up of normal volunteers, patients with epilepsy, and patients with other abnormalities related to the surface of the brain (non-epileptic focal cortical dysfunctions).
Details: This protocol will use positron emission tomography (PET) with H2015 and functional MRI to examine localization of memory and language in normal control subjects, and patients with localization-related epilepsy.
Eligibility:
Study Type:  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Normal Volunteers: The desired age range is 18 to 55 years. Subjects will have no history of head injury or other neurological disease and must not be taking any medication. Female subjects of childbearing potential will be administered a pregnancy test; these subjects will not be eligible for the study requiring 2 scans. All volunteers will read and sign the consent form. Patients: Patients will be selected from among those referred to the Clinical Epilepsy Section, NINDS for evaluation. EXCLUSION CRITERIA: Patients with evidence of a progressive intracranial process, who are taking any drugs (except AEDs) that might affect the results, or active systemic disease will be excluded.
Total Enrollment: 303

Location and Contact Information:

National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda,  Maryland,  20892
United States
 


Additional Information:
Study ID Numbers:  910134;  91-N-0134
Study Start Date: May 15, 1991
Record last reviewed: June 4, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001288

Other Cerebrovascular Disorder Studies:
1. Measurement Of Serum Levels Of Two Antiepileptic Drugs During Conversion In Patients With Epilepsy.

2. Non-Invasive Seizure Localization in Patients with Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings

3. Double-blind, placebo-controlled trial of vitamin E as add-on therapy for children with epilepsy

4. Role of Hormones in Susceptibility to Seizures in Women with Epilepsy

5. Study of Specimens Obtained during Epilepsy Surgery

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