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Home > "B" Clinical Trials Conditions > Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks  Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks
Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks
For Condition: Cardiovascular Diseases
Status: No longer recruiting
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) , National Heart, Lung, and Blood Institute (NHLBI),National Institute on Aging (NIA)
Synopsis: The purpose of this study is to evaluate the effects of meditation on older African Americans with documented cardiovascular disease (CVD).
Details: Cardiovascular disease (CVD) is the leading cause of death and disability in older African Americans, and accounts for 40% of the disproportionate risk for mortality observed in African Americans compared to white Americans. The majority of CVD patients experience acute cardiac events, many sudden and unexpected, despite conventional treatment of their disease and associated traditional risk factors. The pathophysiologic basis of these cardiac events is not fully established, but substantial evidence indicates that psychosocial stress and the sympathetic nervous system have adverse effects on both vasomotor function and long-term autonomic balance. Recent advances in the understanding of the pathophysiology of acute cardiac events-specifically, the roles that arterial vasomotor dysfunction and sympathetic nervous system imbalance play in the pathophysiology of such acute events-provide a platform for a new mechanistic investigation of the interplay of psychosocial and environmental stress and CVD. Preliminary evidence demonstrating elevated peripheral vasoconstriction due to stress-mediated sympathetic nervous system response in African Americans further suggests that these mechanisms are particularly relevant in this group.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Single Blind
Minimum Age/Maximum Age: 65 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - African-American (self-identified) - Local residence - Able to participate - Coronary artery disease by MI, CABG, PTCA (>3 months prior), or angiography - Consent and referring MD approval
Total Enrollment:
Location and Contact Information:
Overall Study Official:
RobertSchneider, Principal Investigator, Center for Health and Aging Studies
Charles R. Drew University of Medicine and Science
Los Angeles, California,
United States
Maharishi University of Management Center for Health and Aging Studies
Fairfield, Iowa, 52557
United States
Additional Information:
Study ID Numbers: 1 P50 AT00082-01P1; 1-P50AT00082-01,5-P50AT00082-02
Study Start Date:
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00010530
Other Cardiovascular Diseases Studies:
1. National Heart, Lung, and Blood Institute Twin Study
2. Health Professionals Follow-up Study
3. Macronutrients and Cardiovascular Risk
4. Carotid Atherosclerosis Follow-up Study
5. Adipose Distribution and Atherosclerosis
Related Studies:
Other Cardiovascular Diseases Clinical Trials
Other Iowa Clinical Trials
Other Fairfield Clinical Trials
Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks
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