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Anticoagulation, Vitamins, and Endothelial Function Clinical Trials Data presented on Clinical Trials Search is not meant to be a substitute for qualified medical advice, visits or professional assistance with a genuine dr.. We are not doctors. Always consult your mD about Anticoagulation, Vitamins, and Endothelial Function conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Anticoagulation, Vitamins, and Endothelial Function Clinical research trials and Anticoagulation, Vitamins, and Endothelial Function medical trials take place in many of places throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectiveness of new does drugs. The purpose of the studies / projects is to solve specific human healthcare questions. Clinical trials are a popular way for mDs, government agencies, and private sector companies to find cures for all varieties of conditions, like Anticoagulation, Vitamins, and Endothelial Function. Anticoagulation, Vitamins, and Endothelial Function Clinical Trials and other clinical trials allow for volunteers to have health treatment options before they are available to the masses. Many times the human subjects acquire professional assistance for free of charge, and sometimes they are compensated for their time. Occasionally there is a cost for a Anticoagulation, Vitamins, and Endothelial Function clinical trial. Test subjects typically obtain the finest healthcare available for their Anticoagulation, Vitamins, and Endothelial Function condition. Dangers are a reality, nevertheless, and might include additional or frequent doctor trips, medical dangers (possibly life-jeopardising), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials patients.
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Home > "A" Clinical Trials Conditions > Anticoagulation, Vitamins, and Endothelial Function  Anticoagulation, Vitamins, and Endothelial Function
Anticoagulation, Vitamins, and Endothelial Function
For Condition: Cardiovascular Diseases
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: Determine whether low or high dose B vitamin therapy will lower homocysteine and thrombomodulin in patients anticoagulated with warfarin.
Details: We hypothesize that 1) both high and low dose B vitamin therapy will lower homocysteine in patients anticoagulated with warfarin and 2) high dose B vitamin therapy will lower thrombomodulin in patients anticoagulated with warfarin. To accomplish these specific aims, we proposed a double- blind randomized controlled trial of 6 months duration comparing 2 different multivitamin regimens differing only in the doses of the following 3 vitamins. The multivitamin for the control group has no folic acid, B2, B6, or B 12. The multivitamin for the intervention group has 5 ing folic acid, 1.7 mg B2, 100 mg B6, and I mg B12. Participants age 50 and older, 150 in each group, are being recruited from the Anticoagulation Clinics at the Baltimore VAMC and neighboring centers. Clinical and risk factor information is being obtained through a face-to-face interview. Blood is being drawn for analyses of homocysteine and vitamin levels (University of Colorado Health Science Center) and thrombomodulin (Baltimore VAMC Hemostasis and Thrombosis Laboratory). Data analysis will be conducted according to the "intention to treat" principle using ordinary least squares regression models.
Eligibility:
Study Type: Interventional, Prevention, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 50 Years/95 Years
Genders: Both
Protocol Entry Criteria: Males and females ages 50 years or greater On warfarin therapy for at least 3 months No active inflammatory process No physician prescribed B vitamins Excluded - women of child-bearing age
Total Enrollment:
Location and Contact Information:
VA Maryland Health Care System *Recruiting*
Baltimore, Maryland, 21201
United States
Recruiting Steven Kittner 410-706-0414
Additional Information:
Study ID Numbers: Epid-004-98F;
Study Start Date: April 1999
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018460
Other Cardiovascular Diseases Studies:
1. Pathways
2. Coronary-Prone Behavior and Cardiovascular Reactivity
3. Epidemiology of Body Mass Index Rebound
4. Ambulatory Blood Pressure and Prognosis
5. Macronutrients and Cardiovascular Risk
Related Studies:
Other Cardiovascular Diseases Clinical Trials
Other Maryland Clinical Trials
Other Baltimore Clinical Trials
Anticoagulation, Vitamins, and Endothelial Function
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