|
Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers Clinical research trials and Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers. Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers clinical trial. Test subjects typically receive the most expert healthcare available for their Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
|
|
|
|
|
|
|
Home > "A" Clinical Trials Conditions > Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers  Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers
Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers
For Condition: Cardiomyopathy, Hypertrophic,Coronary Disease,Healthy,Myocardial Ischemia,Syndrome X
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Myocardial ischemia is a heart condition in which not enough blood supply and oxygen reaches the heart muscle. Damage to the major blood vessels of the heart (coronary artery disease), minor blood vessels of the heart (microvascular heart disease), or damage to the heart muscle (hypertrophic cardiomyopathy) can cause myocardial ischemia. Any of theses three conditions can cause patients to experience chest pain and other symptoms as well as cause the heart to function improperly. In order to detect myocardial ischemia researchers can use tests to measure the movement of the walls of the heart. Walls receiving inadequate supplies of blood often move less and occasionally move in the opposite direction. Some of the tests may require patients to receive injections of radioactive tracers. The radioactive material acts to enhance 3 dimensional pictures of the heart and helps to identify areas of ischemia. The purpose of this study is to determine whether 3-dimensional imaging (tomography) with radioactive tracers can provide more important information about heart wall function than routine diagnostic tests.
Details: We propose to assess regional myocardial function using gated blood pool imaging acquired by a tomographic technique at rest and during stress in patients with myocardial ischemia (coronary artery disease, hypertrophic cardiomyopathy and microvascular angina). Gender differences in response to exercise and pharmacologic stress will also be evaluated. Normal subjects will be studied in order to establish a control database. Current methods of gated blood pool studies use planar imaging, with its attendant limitations; poor resolution and inadequate separation of the myocardial segments, only one view assessed during exercise and superimposition of overlying structures. Tomographic imaging has the advantages of reconstructing 3-dimensional data of the entire heart with the ability to improve segmental resolution and separate overlapping structures, potentially resulting in increased sensitivity and specificity for detection of disease. The role of pharmacologic stress will be assessed by comparison with exercise stress, in order to validate its use in subjects unable to exercise and identify gender related differences. Quantitative measures of regional wall motion obtained from tomography will be compared to regions of prior myocardial infarction (if present), and with other modalities for evaluating cardiac structure and function. The diagnostic and prognostic value of tomographic wall motion analysis will be studied in patients with myocardial ischemia, with special emphasis on correlation between physiologic variables of coronary blood flow and metabolic function.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients with known coronary artery disease (obstruction of greater than or equal to 50% in at least one major coronary artery). Patients with hypertrophic cardiomyopathy. Patients with microvascular angina. No unstable angina. No hepatic or renal failure. Infective endocarditis No primary valvular disease. No congenital heart disease. No pregnant or breast feeding women.
Total Enrollment: 150
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 950048; 95-H-0048
Study Start Date: January 10, 1995
Record last reviewed: January 12, 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001459
Other Cardiomyopathy, Hypertrophic Studies:
1. Treatment of Non-Tuberculous Mycobacterial Infections with Interferon Gamma
2. Effects of Nitrite on Blood Vessel Dilation in Normal Volunteers
3. Prediction and Testing of Antigenic Sites of the AIDS Virus, HTLV-III Recognized by T Lymphocytes for the Development of Synthetic Vaccines
4. Effects of Drugs on Cerebral Blood Flow in Patients with Mood Disorders
5. Bone Mineral Density in Women with Major Depression
Related Studies:
Other Cardiomyopathy, Hypertrophic Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers
|
|
|
|
|
|
|
|
