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Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens Clinical Trials Data presented on Clinical Trials Search is not meant to be a substitute for qualified health advice, visits or treatment with a real mD. We are not doctors. Always consult your doctor about Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens Clinical research trials and Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens healthcare trials happen in many of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new drugs. The purpose of the studies / projects is to solve particular human medical questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to discover cures for all varieties of conditions, such as Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens. Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens Clinical Trials and other clinical trials allow volunteers to have health treatment alternatives before they are available to the masses. Some times the human subjects obtain treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens clinical trial. Test subjects oftentimes receive the most effective healthcare possible for their Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens condition. Dangers are a reality, however, and may include extra or frequent physician visits, healthcare dangers (possibly life-jeopardising), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials patients.
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Home > "A" Clinical Trials Conditions > Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens  Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
For Condition: Aniridia,Eye Abnormality,Ocular Hypertension,Open Angle Glaucoma
Status: Completed
Sponsor(s): National Eye Institute (NEI) ,
Synopsis: This study will investigate congenital or developmental eye abnormalities that affect the iris, cornea and lens, and are usually accompanied by elevated pressure within the eye. These disorders can cause vision loss, and the increased eye pressure can lead to glaucoma, a condition that may also cause loss of eyesight. Patients with eye anterior chamber eye disease, such as Axenfeld's syndrome, Rieger's anomaly, Peter's anomaly, iridocorneal endothelial syndrome, megalocornea, ocular hypertension, and others, are eligible for this study. Participants will have a medical examination, family history, and comprehensive eye examination. Tests and procedures may include photographs of the cornea, iris, and the structure through which fluid that normally circulates behind the cornea drains out of the eye. Some patients may undergo indentation tonography to measure how easily this fluid drains. In this procedure, the patient lies on an examination table and both eyes are numbed with eye drops. A small instrument (tonometer) is placed on the surface of one eye, and with the other eye, the patient looks at an overhead light. Other tests may include photographs of the back of the eye and ultrasound imaging of the structures of the eye. A blood sample may be drawn to study the genetic disorder responsible for the disease. Patients will have follow-up examinations every 6 months for the duration of the study. Medical or surgical therapy will be recommended, as appropriate, for patients who develop elevated eye pressure or vision loss.
Details: This study will concentrate on abnormalities of the anterior chamber with or without elevated intraocular pressure. The purpose of the study will be to determine if there is a common pathogenesis shared by these conditions. A natural history study of 40 individuals with these diseases will utilize clinical measurements and photographs for documentation of this hypothesis. In addition, surgical specimens, when available, will be studied.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: The eye conditions to be studied include Axenfeld's syndrome, Rieger's anomaly, Peter's anomaly, (all with or without glaucoma), Iridocorneal Endothelial syndrome, Aniridia, Pigment Dispersion syndrome, Megalocornea and other conditions with clinical abnormalities of the anterior chamber. Patients will not be included in the study if they do not fit the morphologic characteristics of the disease in question or if the patient's general medical condition or other related factors make it impossible for him or her to continue participation in the study.
Total Enrollment: 100
Location and Contact Information:
National Eye Institute (NEI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 770119; 77-EI-0119
Study Start Date: July 1, 1977
Record last reviewed: August 19, 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001161
Other Ocular Hypertension Studies:
1. Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
Related Studies:
Other Ocular Hypertension Clinical Trials
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Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
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