|
A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator) Clinical Trials References presented on Clinical Trials Search is not intended to be a substitute for proven healthcare advice, trips or professional assistance by using a real medical. We aren't mDs. Always confer with your physician about A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator) conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator) Clinical research trials and A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator) medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectualness of new does drugs. The purpose of the studies / projects is to solve specific human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to discover treatments for all sorts of conditions, such as A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator). A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator) Clinical Trials and other clinical trials permit volunteers to access healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for without cost, and every now and again they are compensated for their time. Sometimes there is a cost for a A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator) clinical trial. Subjects often receive the most expert healthcare possible for their A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator) condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, healthcare dangers (perhaps life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with stern guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "A" Clinical Trials Conditions > A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator)  A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator)
A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator)
For Condition: Acute ischemic stroke
Status: Completed
Sponsor(s): Yamanouchi Pharma America ,
Synopsis: The purpose of this study is to determine if YM872 in combination with t-PA can reduce disability and brain damage from stroke. YM872 or placebo will be given as a continuous intravenous (iv) infusion for 24 hours. It is important that the study medication, YM872 or placebo, is administered prior to the completion of the t-PA administration. The clinical effects of YM872 in addition to t-PA will be determined by assessing neurological function and disability scores at follow up visits through Day 90 of the study.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Patients with acute ischemic stroke who are treated with alteplase within 3 hours of stroke onset (Onset is defined as the time that which the patient was last seen in a normal state, or bedtime for unwitnessed strokes occurring during the night). - Patients who are able to provide written informed consent or have consent provided by a legally authorized representative. - Patients who are at least 18 years of age. - Patients who have a National Institutes of Health Stroke Scale (NIHSS) score of at least 7 but not more than 23 and who are conscious. - Other criteria as specified in the study protocol Exclusion Criteria: - Patients who are not eligible to receive treatment with alteplase (t-PA) due to brain hemorrhage, risk for hemorrhage, or other criteria. - Patients who have stroke of the brainstem or cerebellum. - Patients who have renal (kidney) disease or insufficiency. - Patients who have active epilepsy or convulsions during the current stroke episode. - Patients who are IV drug users or are inebriated. - Patients who have a history of drug-related anaphylaxis. - Patients who have taken sedatives, anticonvulsants, or any medication with sedating effects in the 10 days prior study enrollment. - Patients who have taken more than 1.3 g of aspirin per day in the 2 days prior to enrollment. - Patients who have a known vitamin hypersensitivity. - Other exclusion criteria as specified by the study protocol
Total Enrollment:
Location and Contact Information:
Universitätsklinikum Leipzig
Leipzig, ,
Germany
Tampa General Hospital
Tampa, Florida,
United States
Charles LeMoyne Hospital
Greenfield Park, Quebec,
Canada
St Francis Hospital
Columbus, Georgia,
United States
Universität zu Köln klinik und poliklinik fur neurology
Köln, ,
Germany
Beth Israel Deaconess Medical Center
Boston, Massachusetts,
United States
Long Island Jewish Medical Center
New Hyde Park, New York,
United States
Victoria General Hospital
Victoria, British Columbia,
Canada
John Muir Medical Center
Walnut Creek, California,
United States
Scripps Mercy Hospital
San Diego, California,
United States
Stanford University Medical Center
Palo Alto, California,
United States
Scripps Memorial Hospital
Encinitas, California,
United States
Methodist Hospital
Indianapolis, Indiana,
United States
Roper Hospital
Charleston, South Carolina,
United States
Advanced Neurology Specialists (Benefis Healthcare Hospital)
Great Falls, Montana,
United States
Neurology Klinik Klinikum Hanover
Hanover, ,
Germany
Good Samaritan Hospital
San Jose, California,
United States
St Joseph's Hospital
Tampa, Florida,
United States
Michigan State University
East Lansing, Michigan,
United States
Mercy General Hospital
Sacramento, California,
United States
OSF St. Francis Medical Center
Peoria, Illinois,
United States
Albert Einstein Medical Center
Philadelphia, Pennsylvania,
United States
Chattanooga Neurology Associates (Erlanger Hospital)
Chattanooga, Tennessee,
United States
University Essen
ESSEN, ,
Germany
Friedrich-Schiller-University
Jena, ,
Germany
University of Pennsylvania Medical Center
Philadelphia, Pennsylvania,
United States
Good Samaritan Hospital
Phoenix, Arizona,
United States
Culicchia Neurology Clinic, LLP
Marrero, Louisiana,
United States
University of New Mexico Hospital
Albuquerque, New Mexico,
United States
Stony Brook Hospital
Stony Brook, New York,
United States
Riverside Methodist Hospital
Columbus, Ohio,
United States
Medical College of Ohio
Toledo, Ohio,
United States
Notre-Dame Hospital
Montreal, Quebec,
Canada
Stevens Memorial Hospital
Edmonds, Washington,
United States
JFK Medical Center
Edison, New Jersey,
United States
Providence St. Peter Hospital
Olympia, Washington,
United States
Neurology Associates, Inc. (St. Mary's Hospital)
Richmond, Virginia,
United States
William Beaumont Hospital
Royal Oak, Michigan,
United States
Neurology Group of Bergen County (Valley Hospital)
Ridgewood, New Jersey,
United States
Ellis Hospital
Schenectady, New York,
United States
Bridgeport Hospital
Bridgeport, Connecticut,
United States
Candler Hospital
Savannah, Georgia,
United States
Neurologische Klinik Knappschafts - krankenhause
Recklinghausen, ,
Germany
Dienst Neurologie UZ Gasthuisberg
Leuven, ,
Belgium
St. Elizabeth Health Center
Youngstown, Ohio,
United States
St. Luke's Medical Center
Milwaukee, Wisconsin,
United States
Universitätskrankenhaus Hamburg-Eppendorf Klinik für Neurologie
Hamburg-Eppendorf, ,
Germany
Akron General Medical Center
Akron, Ohio,
United States
Providence St. Joseph's Medical Center
Burbank, California,
United States
Chattanooga Neurology Associates (Memorial Hospital)
Chattanooga, Tennessee,
United States
Rochester General Hospital
Rochester, New York,
United States
University of Texas (Houston Medical Center)
Houston, Texas,
United States
Neurological Research Center, Inc
Bennington, Vermont,
United States
Queen's Medical Center
Honolulu, Hawaii,
United States
DNA Research (Dekalb Medical Center)
Decatur, Georgia,
United States
St Joseph Hospital
Savannah, Georgia,
United States
Roosevelt Hospital
New York City, New York,
United States
Metrohealth Medical Center
Cleveland, Ohio,
United States
VA Medical Center
Albuquerque, New Mexico,
United States
Muhlenberg Regional Medical Center
Plainfield, New Jersey,
United States
Bethesda Memorial Hospital
Boynton Beach, Florida,
United States
Northern Michigan Neurology
Traverse City, Michigan,
United States
Tri-City Medical Center
Oceanside, California,
United States
Miriam Hospital
Providence, Rhode Island,
United States
Pavillion St Joseph
Trois Rivers, Quebec,
Canada
Washoe Comprehensive Stroke Center
Reno, Nevada,
United States
University of California Davis Medical Center
Davis, California,
United States
University of South Alabama Stroke Center
Mobile, Alabama,
United States
East Bay Region Associates in Neurology
Berkeley, California,
United States
Universitätsklinik Mainz
Mainz, ,
Germany
Lehigh Valley Hospital
Allentown, Pennsylvania,
United States
St. Luke's Hospital
New York City, New York,
United States
Hershey Medical Center
Hershey, Pennsylvania,
United States
UCLA Medical Center
Los Angeles, California,
United States
Vanderbilt University Medical Center
Nashville, Tennessee,
United States
University of Pittsburgh Medical Center Stroke Institute
Pittsburgh, Pennsylvania,
United States
St. Thomas Hospital
Nashville, Tennessee,
United States
St John's Hospital
Detroit, Michigan,
United States
North Shore University Hospital
Manhasset, New York,
United States
Columbia Presbyterian Medical Center
New York City, New York,
United States
Colorado Neurological Institute
Englewood, Colorado,
United States
Universitätsklinikum Aachen, Neurologische Klinik
Aachen, ,
Germany
University of Alberta Hospital
Edmonton, Alberta,
Canada
New England Medical Center
Boston, Massachusetts,
United States
Parkview Hospital
Ft. Wayne, Indiana,
United States
Royal Jubilee Hospital
Victoria, British Columbia,
Canada
Universitätsklinik allgemeines Krankenhaus der Stadt Wien
Wien, ,
Austria
Buffalo General Hospital
Buffalo, New York,
United States
Louisville Neuroscience Research Center
Louisville, Kentucky,
United States
University of California at San Diego
San Diego, California,
United States
Penticton Regional Hospital
Penticton, British Columbia,
Canada
Columbia JFK Hospital
Atlantis, Florida,
United States
University of Arizona
Tucson, Arizona,
United States
Grossmont Hospital
La Mesa, California,
United States
Bi-County Hospital
Warren, Michigan,
United States
Mt Diablo Medical Center
Walnut Creek, California,
United States
UCLA Medical Center - Santa Monica
Santa Monica, California,
United States
Holmes Regional Medical Center
Melbourne, Florida,
United States
Neurologische Universitätsklinik
Freiburg, ,
Germany
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania,
United States
Neurologisch Psychiayrische Klinik
Weisbaden, ,
Germany
Lakeland Regional Medical Center
Lakeland, Florida,
United States
Mercy San Juan Hospital
Carmichael, California,
United States
Bay Medical Center
Panama City, Florida,
United States
University of Maryland Medical System
Baltimore, Maryland,
United States
Vancouver General Hospital
Vancouver, British Columbia,
Canada
Rowan Regional Medical Center
Winston Salem, North Carolina,
United States
Albany Medical Center
Albany, New York,
United States
Westmoreland Regional Hospital
Greensburg, Pennsylvania,
United States
Research Medical Center
Kansas City, Missouri,
United States
Virginia Beach General Hospital
Virginia Beach, Virginia,
United States
Geisinger Medical Center
Danville, Pennsylvania,
United States
Crozer Chester Medical Center
Upland, Pennsylvania,
United States
Theda Clark Medical Center
Neenah, Wisconsin,
United States
Forsyth Medical Center
Winston Salem, North Carolina,
United States
Neurologische Klinik Klinikum Rechts der Isar der TU Munchen
Munchen, ,
Germany
Royal University Hospital
Saskatoon, Saskatchewan,
Canada
Foothills Medical Centre
Calgary, Alberta,
Canada
Additional Information:
Study ID Numbers: 872-CL-004;
Study Start Date: December 2000
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00044057
Other Acute Ischemic Stroke Studies:
1. Safety, Efficacy, and Tolerability of Repinotan in Patients with Acute Ischemic Stroke
2. A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator)
Related Studies:
Other Acute ischemic stroke Clinical Trials
Other Clinical Trials
Other ESSEN Clinical Trials
A study to evaluate the effects of YM872 on brain function and disability when administered in combination with alteplase (tissue plasminogen activator)
|
|
|
|
|
|
|
|
