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A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations Clinical research trials and A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations. A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations clinical trial. Participants typically obtain the most effective healthcare available for their A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "A" Clinical Trials Conditions > A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations  A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations
A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations
For Condition: HIV Infections
Status: Completed
Sponsor(s): Merck ,
Synopsis: The purpose of this study is to compare two different anti-HIV drug combinations, one that contains nelfinavir (NFV) and one that does not. The best dosing schedule for indinavir (IDV) also will be studied.
Details: Patients are stratified by screening plasma viral RNA results (50,000 copies/ml or below vs above 50,000 copies/ml) and randomized to 1 of 2 treatment arms. Group 1 receives IDV 3 times daily plus d4T/3TC twice daily. Group 2 receives IDV/NFV/d4T/3TC twice daily. Patients remain on study medications for 24 weeks and are seen at the clinic once every 4 weeks after entering the study. At each clinic visit, blood samples are taken to evaluate CD4 cell count and plasma HIV RNA levels.
Eligibility:
Study Type: Interventional, Treatment, Safety Study
Minimum Age/Maximum Age: 16 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria You may be eligible for this study if you: - Are HIV positive. - Have a viral load (level of HIV in your blood) of at least 10,000 copies/ml within 45 days of study entry. - Have a CD4 cell count of at least 100 cells/mm3 within 45 days of study entry. - Have a normal chest X-ray. - Have never taken protease inhibitors or 3TC. - Are 16 years of age or older. - Agree to practice sexual abstinence or use barrier methods of birth control (e.g., condoms). Exclusion Criteria You will not be eligible for this study if you: - Have an active opportunistic (AIDS-related) infection or cancer. - Have certain types of Kaposi's sarcoma. - Have hepatitis. - Have chronic diarrhea. - Have a history of certain medical conditions. - Are allergic to any of the study medications. - Are taking certain medications. - Are pregnant or breast-feeding.
Total Enrollment: 220
Location and Contact Information:
Denver Public Health Dept
Denver, Colorado, 80204
United States
The Research and Education Group
Portland, Oregon, 97210
United States
Institute of Human Virology
Baltimore, Maryland, 21201
United States
Univ of Alabama School of Med
Montgomery, Alabama, 36116
United States
Associates in Med and Mental Health
Tulsa, Oklahoma, 74114
United States
Infections Ltd / Physicians Med Ctr
Tacoma, Washington, 98405
United States
AIDS Healthcare Foundation
Los Angeles, California, 90027
United States
Oasis Clinic / King Drew Med Ctr
Los Angeles, California, 90059
United States
Education & Research Building
Camden, New Jersey, 08103
United States
Harold Katner MD
Macon, Georgia, 31202
United States
Brookdale Univ Hosp and Med Ctr
Brooklyn, New York, 112123198
United States
Univ TX Galveston Med Branch
Galveston, Texas, 77555
United States
Robert Scott MD
Oakland, California, 94609
United States
AIDS Consultation Service / Maine Med Ctr
Portland, Maine, 04102
United States
JSI Research and Training Institute
Boston, Massachusetts, 02210
United States
Fanno Creek Clinic
Portland, Oregon, 97219
United States
Anderson Clinical Research / Inc
Pittsburgh, Pennsylvania, 15213
United States
Univ of Illinois
Chicago, Illinois, 60612
United States
IDC Research Initiative
Altamonte Springs, Florida, 32701
United States
Blick Med Associates
Stamford, Connecticut, 06901
United States
Pacific Horizons Med Group
San Francisco, California, 94115
United States
Kentucky Clinical Research
Lexington, Kentucky, 40504
United States
Tower ID Med Associates
Los Angeles, California, 90048
United States
AIDS Community Research Consortium
Redwood City, California, 94063
United States
NJCRI
Newark, New Jersey, 07103
United States
Burnside Clinic
Columbia, South Carolina, 29206
United States
Emory Univ
Atlanta, Georgia, 30308
United States
Community Health Network
Rochester, New York, 14620
United States
Thomas Coffman MD
Boise, Idaho, 83712
United States
James Jones MD
New York City, New York, 10019
United States
Oak Lawn Physicians Group
Dallas, Texas, 75219
United States
Harbor - UCLA Med Ctr
Torrance, California, 90502
United States
Mount Sinai Med Ctr
New York City, New York, 10029
United States
Vanderbilt Univ Med Ctr
Nashville, Tennessee, 37203
United States
Louisiana State Univ Med Ctr / Tulane Med School
New Orleans, Louisiana, 70112
United States
Kaiser Foundation Hospital
San Francisco, California, 94118
United States
Wake Forest Univ School of Medicine
Winston Salem, North Carolina, 27157
United States
Hillsborough County Health Dept
Tampa, Florida, 33602
United States
Chicago Ctr for Clinical Research
Chicago, Illinois, 60610
United States
Liberty Med Group
New York City, New York, 10016
United States
Infectious Disease Specialists of NJ
Union, New Jersey, 07083
United States
Saint Francis Mem Hosp / HIV Care Unit
San Francisco, California, 94109
United States
Ocean View Internal Medicine
Long Beach, California, 90803
United States
Univ of Miami School of Medicine
Miami, Florida, 33136
United States
Physicans Home Service
Washington D.C., District of Columbia, 20037
United States
Northwestern Univ Med Ctr
Chicago, Illinois, 60611
United States
Additional Information:
Study ID Numbers: 246R; 079-02,CRX454
Study Start Date:
Record last reviewed: February 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002430
Other Hiv Infections Studies:
1. A Study of Saquinavir Soft Gel Capsules (SGC) Used in Combination With Two Other Anti-HIV Drugs in Patients with HIV-Associated Kidney Disease
2. Phase I Safety and Immunogenicity Trial of Vaccinia-HIV Envelope Recombinant Vaccine (HIVAC-1e) in Combination with Soluble Recombinant Envelope Vaccine (gp160; VaxSyn)
3. A Study of Treatments for Fungal Infections of the Mouth and Throat in HIV-Infected Patients Who Have Had Success with Itraconazole But Not with Fluconazole
4. Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis carinii Pneumonia Prophylaxis
5. A Study to Demonstrate that Anti-HIV Drug Therapy can be Stopped Without Causing Viral Resistance, and to Characterize Drug Elimination from the Body
Related Studies:
Other HIV Infections Clinical Trials
Other Louisiana Clinical Trials
Other New Orleans Clinical Trials
A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations
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