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A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients Clinical Trials Information presented on Clinical Trials Search is not intended to be a substitute for qualified health advice, trips or treatment by using a genuine doctor. We aren't doctors. Always consult your mD on A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients Clinical research trials and A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients health trials take place in a lot of of cities across the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the potency of new drugs. The aim of the studies / projects is to answer specific human medical questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to discover remedies for all kinds of circumstances, like A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients. A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients Clinical Trials and other clinical trials allow for volunteers to have health treatment alternatives before they are available to the general public. Many times the test subjects obtain treatment for without cost, and occasionally they are paid for their time. Sometimes there is a cost for a A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients clinical trial. Subjects oftentimes recieve the most effective healthcare possible for their A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients condition. Hazards are a reality, however, and could include additional or frequent doctor visits, healthcare dangers (perhaps life-threatening), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
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Home > "A" Clinical Trials Conditions > A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients  A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients
A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients
For Condition: HIV Infections
Status: Completed
Sponsor(s): Abbott Laboratories ,
Synopsis: The purpose of this study is to determine how many HIV-infected patients continue taking ritonavir/indinavir combination after having taken indinavir three times a day as part of their anti-HIV drug therapy. This study also examines the safety and effectiveness of the ritonavir/indinavir combination.
Details:
Eligibility:
Study Type: Interventional, Treatment, Safety Study
Minimum Age/Maximum Age: 12 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients must have: - HIV infection. - CD4 cell count greater than 100 cells/microliter. - HIV RNA levels greater than 400 copies/microliter using the Roche Ultrasensitive assay. - No acute illness. - Consent of parent or guardian if less than legal age. - No prior enrollment in this study. - All entry criteria for this study met within 15 days prior to enrollment. Exclusion Criteria Co-existing Condition: Patients with any of the following symptoms or conditions are excluded: Any condition that in the opinion of the investigator may obscure proper observation of the safety or activity of the treatment regimens used in this study. Concurrent Medication: Excluded: - Concurrent non-nucleoside reverse transcriptase inhibitors as part of the antiretroviral regimen. - Any of the following medications with ritonavir: - midazolam, clorazepate, diazepam, estazolam, flurazepam, triazolam, zolpidem, quinidine, amiodarone, encainide, flecainide, propafenone, bepridil, terfenadine, astemizole, cisapride, bupropion, clozapine, rifabutin, meperidine, propoxyphene, piroxicam, pimozide, dihydroergotamine, and ergotamine. - Any of the following medications with indinavir: - terfenadine, astemizole, cisapride, triazolam, midazolam. No requirement for rifampin or ketoconazole. - Any concurrent treatment with other protease inhibitors. - Other concurrent medication (including over-the-counter medicine or alcohol) without the knowledge and permission of the primary investigator. Patients with the following prior conditions are excluded: - History of significant drug hypersensitivity. - Psychiatric illness that precludes compliance with the protocol. - Receipt of investigational drug within 30 days prior to administration of study drug. - History of acute or chronic pancreatitis. - Anticipation of poor patient compliance with protocol. Prior Medication: Excluded: Prior treatment with ritonavir. Risk Behavior: Excluded: History of active substance abuse (i.e., recreational drugs or alcohol). Included: Indinavir 800 mg three times a day plus unspecified nucleosides for at least 3 months.
Total Enrollment:
Location and Contact Information:
Stephen Hauptman
Philadelphia, Pennsylvania, 19107
United States
Tower Infectious Diseases
Los Angeles, California, 90048
United States
Goodgame Med Ctr / Central Florida Research Initiati
Maitland, Florida, 32751
United States
AIDS Healthcare Foundation
Los Angeles, California, 90027
United States
Urgent Care Ctr / North Broward Hosp District
Ft. Lauderdale, Florida, 33316
United States
Mount Sinai Med Ctr
New York City, New York, 10029
United States
Additional Information:
Study ID Numbers: 245E; M98-823
Study Start Date:
Record last reviewed: April 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002223
Other Hiv Infections Studies:
1. Treatment of Acute HIV Infection to Preserve Immune Function
2. The Safety and Effectiveness of Different Doses of Vitamin C in HIV-Infected Patients
3. An Open Trial Combining Zidovudine, Interferon-alfa, and Recombinant CD4-IgG With Transplantation of Syngeneic Bone Marrow and Peripheral Blood Lymphocytes From Healthy gp160-Immunized Donors in the Treatment of Patients With HIV Infection
4. A Phase I Study of Autologous, Activated CD8(+) Lymphocytes Expanded In Vitro and Infused With or Without Recombinant Interleukin-2 to Patients With AIDS or Severe ARC
5. A Comparison of Epivir Plus Crixivan Combined with Zerit or Retrovir in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
Related Studies:
Other HIV Infections Clinical Trials
Other Florida Clinical Trials
Other Ft. Lauderdale Clinical Trials
A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients
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