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A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow Transplant



A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow Transplant

For Condition: Lymphoma, Non-Hodgkin,HIV Infections
Status: Completed
Sponsor(s): Glaxo Wellcome ,
Synopsis: To determine whether zidovudine (AZT) in conjunction with bone marrow transplantation prevents the reinfection of donor hematopoietic/lymphoid cells in patients with positive HTLV III antibody and large cell/diffuse histiocytic lymphoma. Patients who are candidates will be evaluated for HTLV III activity and drug levels.
Details:
Eligibility:
Study Type:  Interventional, Treatment, Dose Comparison
Minimum Age/Maximum Age: 12 Years/50 Years
Genders: Both
Protocol Entry Criteria: Exclusion Criteria Co-existing Condition: Patients with current life-threatening infection at time of transplant that would preclude a transplant are excluded. Concurrent Medication: Excluded: - Other anti-retroviral agents. Patients with current life-threatening infection at time of transplant that would preclude a transplant are excluded. Patients must be: - HTLV III antibody positive by ELISA or Western blot or HTLV III viremia. - At high mortal risk with a diagnosis of AIDS or AIDS Related Complex (ARC). - Also patient must fall into one of the following categories: - Have an HIV seronegative identical twin to serve as a bone marrow donor. - Have documentation of large cell/diffuse histiocytic lymphoma/DPDL. - Be a good risk candidate for bone marrow transplant.
Total Enrollment: 

Location and Contact Information:

Johns Hopkins Hemapheresis Treatment Ctr
Baltimore,  Maryland,  21205
United States
 


Additional Information:
Study ID Numbers:  014A;  006
Study Start Date: 
Record last reviewed: February 1995
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002284

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