|
A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified health advice, travels to or treatment by using a genuine physician. We are not physicians. Always consult your dr. on A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma Clinical research trials and A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma health trials occur in hundreds of cities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new drugs. The propose of the studies / undertakings is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector companies to locate treatments for all sorts of conditions, including A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma. A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma Clinical Trials and other clinical trials permit volunteers to acquire medical treatment choices before they are available to the masses. Some times the test subjects obtain professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma clinical trial. Participants oftentimes recieve the most expert healthcare available for their A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma condition. Hazards are a reality, however, and can include extra or frequent physician visits, health risks (potentially life-endangering), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "A" Clinical Trials Conditions > A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma  A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma
A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma
For Condition: Adenocarcinoma, Renal Cell,Carcinoma, Renal Cell,Kidney Neoplasms
Status: No longer recruiting
Sponsor(s): Eisai Medical Research Inc ,
Synopsis: The purpose of this study is to determine if E7070 is a safe and effective treatment for cancer of the kidneys.
Details: Renal Cell Carcinoma (RCC) accounts for approximately 2% of all cancers and its incidence is increasing with worldwide deaths of over 100,000 patients per year. About 50% of RCC patients have inoperable or metastatic disease that surgery cannot be performed on. RCC is also considered to be resistant to both radiotherapy and cytotoxic chemotherapy. The purpose of this study is to evaluate the safety and effectiveness of E7070 by assessing progression free survival, tumor response rate, duration of response/stable disease, and survival time. E7070 will be administered as a single iv infusion over 60 minutes on Day 1 of each cycle. Patients will continue treatment with E7070 until they no longer have clinical benefit and have disease progression, or toxicity leads to patient withdrawal.
Eligibility:
Study Type: Interventional, Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Age >=18 years old. - Have histologically/cytologically confirmed clear cell RCC. - Previously untreated or one prior treatment with immunotherapy (one prior treatment may be represented by single agent interferon, single agent interleukin-2 or a combination of interferon with interleukin-2 with or without accompanying hematological growth factors). - Documented evidence of progressive disease in the previous 3 months. In the absence of radiographic studies, patients may be entered on the study if they have clinical evidence of progressive disease. - Have at least one unidimensional measurable lesion of RCC according to the RECIST guidelines. The following will not qualify as measurable lesions: bone, leptomeningeal disease, ascites, pleural/pericardial effusion, lymphangitis cutis/pulmonis, abdominal masses that are not confirmed and followed by imaging techniques, and cystic lesions. - Be ambulatory and have a Karnofsky performance status >=70%. - Have a life expectancy of at least 3 months. - Give written informed consent prior to any study-specific screening procedures, with the understanding that the consent may be withdrawn by the patient at any time without prejudice. - Be willing and able to comply with the study protocol for the duration of the study. Exclusion Criteria: - Woman who are pregnant or breastfeeding. Women of childbearing potential with either a positive pregnancy test at screening or no pregnancy test. Women of childbearing potential unless (1) surgically sterile or (2) using adequate contraceptive measures (postmenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential). - Fertile male subjects not willing to use contraception and whose female partners are not under adequate contraceptive protection. - Known CNS metastases (if clinical suspicion of CNS metastases exists appropriate imaging must be performed prior to study entry). - Prior treatment with chemotherapy (there is no restriction on prior epidermal growth factor directed therapy). - Severe and uncontrolled cardiac or cardiovascular abnormalities. - Severe uncontrolled intercurrent infections. - Subjects with organ allografts. - Any of the following abnormal screening hematological values: Hemoglobin (Hb) <9g /dL (6 mmol/L), Neutrophils <1.5 x 10^9/L, Platelets <100 x 10^9/L. - Blood transfusions or growth factors to aid hematological recovery within 2 weeks prior to starting study treatment. - Any of the following abnormal screening liver function tests: serum bilirubin >= 1.5 x upper normal limit (ULN), alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) >= 2.5 x ULN (unless related to liver metastases in which case >= 5 x ULN). - The following abnormal screening renal function tests: either a serum creatinine > 1.5 x ULN or a creatinine clearance (estimated from serum creatinine) < 40 mL/minute. - Prior radiotherapy (except palliative). - Participation in any investigational drug study or immunotherapy within 4 weeks preceding treatment start. - History of hypersensitivity to sulphonamides. - Any concurrent or previous malignancy of a different tumor type within 5 years of starting E7070 treatment except for adequately treated non-melanoma skin cancer or cervical intra-epithelial neoplasia. - Significant disease, which in the Investigator’s opinion would exclude the patient from the study. - Surgically resectable metastatic disease. - Legal incapacity.
Total Enrollment: 30
Location and Contact Information:
Overall Study Official:
MurrayYule, Study Director, Eisai Ltd.
Additional Information:
Study ID Numbers: E7070-A001-206;
Study Start Date: May 2002
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00059735
Other Kidney Neoplasms Studies:
1. A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma
Related Studies:
Other Kidney Neoplasms Clinical Trials
Other California Clinical Trials
Other Sacramento Clinical Trials
A Safety, Tolerability and Efficacy Study of E7070 in Patients with Renal Cell Carcinoma
|
|
|
|
|
|
|
|
