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A Phase I Study of ARQ 501 in Subjects with Cancer



A Phase I Study of ARQ 501 in Subjects with Cancer

For Condition: Cancer
Status: Recruiting
Sponsor(s): ArQule ,
Synopsis: ARQ 501, an investigational anticancer drug, is intended to selectively kill cancer cells and spare normal cells by restoring and activating cellular checkpoints known to be defective in cancer using the Company’s unique biology platform, Activated Checkpoint Therapy™ (ACT). ARQ 501 has the potential for improved activity and reduced toxicity over other molecular approaches and traditional cancer chemotherapy.
Details:
Eligibility:
Study Type:
  Interventional,Treatment,Non-Randomized,Open Label,Active Control,Single Group Assignment,Safety Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria - Histologically or cytologically confirmed solid tumor that is metastatic, unresectable or recurrent and for which standard curative or palliative measures do not exist or are no longer effective. - ECOG performance status greater than or equal to 1 - Life expectancy greater than three months - Acceptable pretreatment clinical laboratory results Exclusion Criteria - Subjects who have had chemotherapy or radiotherapy within 4 weeks - Subjects receiving any other investigational agents - Subjects with known untreated brain metastases - Subjects receiving hepatic enzyme-inducing antiseizure drugs (“EIASD”) - Subjects with uncontrolled intercurrent illnesses - Pregnant women
Total Enrollment: 30

Location and Contact Information:

Dana Farber/Partners CancerCare Inc *Recruiting*
Boston,  Massachusetts,  02115
United States
Recruiting Tracy  Bell 617-632-3482


Additional Information:
Study ID Numbers:
  ARQ 501-101; 
Study Start Date: September 2003
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00075933

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