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A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes Clinical Trials Information presented on Clinical Trials Search isn't intended to be a substitute for proven healthcare advice, trips or treatment using a real physician. We are not docs. Always confer with your mD on A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes Clinical research trials and A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectiveness of new drugs. The intention of the studies / projects is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector corporations to detect remedies for all forms of circumstances, like A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes. A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes Clinical Trials and other clinical trials allow for volunteers to undergo healthcare treatment options before they are available to the masses. Most times the participants receive treatment for free, and every now and again they are paid for their time. Occasionally there is a cost for a A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes clinical trial. Subjects typically recieve the finest healthcare available for their A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes condition. Hazards are a reality, nonetheless, and might include more or frequent mD trips, health risks (potentially life-endangering), and/or the treatment being ineffective. Trials are federally regulated with stern guidelines to protect clinical trials subjects.
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Home > "A" Clinical Trials Conditions > A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes
A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes
For Condition: Cytomegalovirus Retinitis,HIV Infections
Status: Completed
Sponsor(s): Roche Global Development ,
Synopsis: To investigate the efficacy and safety of RS-79070 when used as induction therapy in patients with newly diagnosed peripheral retinitis. To assess the effects of induction and maintenance level dosing of RS-79070 on CMV viral load, estimated by plasma CMV PCR. To assess the pharmacokinetics of ganciclovir following administration of RS-79070 in the target population.
Details: Patients will be randomized to 1 of 2 treatment groups. Group A will receive iv ganciclovir for 3 weeks, then iv ganciclovir for 1 week. Group B will receive RS-79070 bid for 3 weeks then RS-790070 qd for 1 week. After the initial 4 week treatment period, patients from both groups will then be offered entry into a long-term follow-up phase of the study where they will receive RS-79070 qd.
Eligibility:
Study Type: Interventional, Treatment, Parallel Assignment, Pharmacokinetics Study
Minimum Age/Maximum Age: 14 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients must have: - Documented AIDS diagnosis. - Newly diagnosed peripheral CMV retinitis. More than 3 weeks of previous therapy for CMV retinitis.
Total Enrollment: 70
Location and Contact Information:
Duke Univ Eye Ctr
Durham, North Carolina, 27710
United States
Davies Med Ctr / Institute for HIV Research
San Francisco, California, 94114
United States
Emory Eye Clinic
Atlanta, Georgia, 30322
United States
QUEST Clinical Research
San Francisco, California, 94115
United States
Univ of California / San Diego / Dept of Pediatrics
La Jolla, California, 92093
United States
New York Hosp - Cornell Med Ctr
New York City, New York, 10021
United States
The Toronto Hosp / Dept of Infectious Disease
Toronto, Ontario,
Canada
Univ of Miami School of Medicine
Miami, Florida, 33136
United States
Univ of California / Irvine
Irvine, California, 92697
United States
St Luke's - Roosevelt Hosp Ctr / Div of Infect Dis
New York City, New York, 10019
United States
Univ of California / San Diego Treatment Ctr
San Diego, California, 92103
United States
Montreal Chest Institute
Montreal, Quebec,
Canada
New York Univ Med Ctr
New York City, New York, 10016
United States
Austin Infectious Disease Consultants
Austin, Texas, 78705
United States
Royal Victoria Hosp
Montreal, Quebec,
Canada
New England Med Ctr
Boston, Massachusetts, 02111
United States
Kaiser Permanente Med Ctr
San Francisco, California, 94115
United States
St Pauls Hosp
Vancouver, British Columbia,
Canada
Dr Alan Palestine
Washington D.C., District of Columbia, 20006
United States
Additional Information:
Study ID Numbers: 268A; WV15376B
Study Start Date:
Record last reviewed: April 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002377
Other Hiv Infections Studies:
1. Suppression of Cytomegalovirus Retinitis Utilizing High Dose Intravenous Acyclovir and Oral Zidovudine in Patients With AIDS
2. A Study of Two Forms of Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients with AIDS
3. The Safety and Effectiveness of Ganciclovir in the Prevention of Cytomegalovirus (CMV) of the Eyes and Disease of the Stomach and Intestines in Patients with HIV
4. Studies of the Ocular Complications of AIDS (SOCA)--Monoclonal Antibody CMV Retinitis Trial (MACRT)
5. A Comparison of HIV-Infected Patients with and without Opportunistic (AIDS-Related) Infection
Related Studies:
Other HIV Infections Clinical Trials
Other Florida Clinical Trials
Other Miami Clinical Trials
A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes
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