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A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems Clinical research trials and A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems. A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems clinical trial. Participants oftentimes recieve the finest healthcare available for their A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.

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A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems



A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems

For Condition: Candidiasis, esophageal,HIV Infections
Status: Completed
Sponsor(s): Pfizer ,
Synopsis: To compare the safety, tolerance, and effectiveness of fluconazole and ketoconazole in the treatment of candidal esophagitis in immunocompromised patients.
Details:
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: 13 Years/70 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Prior Medication: Allowed: - Cyclosporin if levels can be monitored for proper cyclosporin dose adjustment. Exclusion Criteria Co-existing Condition: Patients with the following are excluded: - Evidence of noncandidal systemic fungal infections. - Leukopenia (white blood cell count less than 1000/mm3), or expected to develop leukopenia during the study. - Other condition known to be associated with poor ketoconazole absorption, e.g., hypochlorhydria. - Leukemia requiring chemotherapy. - Any other condition which in the opinion of the investigator would make the patient unsuitable for enrollment. Concurrent Medication: Excluded: - Warfarin. - Immunostimulants. - Interferon. - Oral or topical antifungal agents. Concurrent Treatment: Excluded: - Lymphocyte replacement. Patients with the following are excluded: - History of allergy to imidazoles. - Abnormalities which may preclude esophagoscopy or endoscopy before or during the study. - Inability to tolerate fluconazole or ketoconazole. - Inability or unwillingness to give written informed consent. - Life expectancy < 2 months. Prior Medication: Excluded: - Rifampin or ansamycin, pending clarification of drug interactions between these drugs and fluconazole. - Warfarin. Patients must meet the CDC criteria for the diagnosis of AIDS or be otherwise immunocompromised (e.g., malignancy, renal transplant) and have a diagnosis of oral candidiasis and/or esophageal symptoms of dysphagia and/or odynophagia. Illicit or illegal drug use.
Total Enrollment: 

Location and Contact Information:

Wilson Brailsford Clinic
Spartanburg,  South Carolina,  29304
United States
 

Buckley Braffman Stern Med Associates
Philadelphia,  Pennsylvania,  19107
United States
 

Infectious Disease Physicians Inc
Annandale,  Virginia,  22203
United States
 

Audie L Murphy Veterans Administration Hosp
San Antonio,  Texas,  78284
United States
 

Virginia Mason Med Ctr
Seattle,  Washington,  98101
United States
 

Leila Hosp and Health Care Ctr
Battle Creek,  Michigan,  49016
United States
 

Roswell Park Memorial Institute
Buffalo,  New York,  14263
United States
 

Georgia Baptist Med Ctr
Atlanta,  Georgia,  30338
United States
 

Bowman Gray School of Medicine / North Carolina Baptist Hosp
Winston Salem,  North Carolina,  27103
United States
 

Clayton Gen Hosp
Riverdale,  Georgia,  30274
United States
 

Ctr for Special Immunology
Ft. Lauderdale,  Florida,  33308
United States
 

Univ Hosp
Boston,  Massachusetts,  02118
United States
 

Holland Community Hosp
Holland,  Michigan,  49423
United States
 

Med Ctr Clinic
Pensacola,  Florida,  325241151
United States
 

Munson Med Ctr
Traverse City,  Michigan,  49684
United States
 

Dr Winkler Weinberg
Roswell,  Georgia,  30076
United States
 

Univ TX San Antonio Health Science Ctr
San Antonio,  Texas,  78284
United States
 

Butterworth Hosp
Grand Rapids,  Michigan,  49503
United States
 

Dr Eugene Speck
Las Vegas,  Nevada,  89109
United States
 

Univ of Tennessee
Memphis,  Tennessee,  38163
United States
 

Cornell Univ Med Ctr
New York City,  New York,  10021
United States
 

SUNY / Health Sciences Ctr at Brooklyn
Brooklyn,  New York,  11203
United States
 

Baystate Med Ctr of Springfield
Springfield,  Massachusetts,  01199
United States
 

Univ of New Mexico School of Medicine
Albuquerque,  New Mexico,  87131
United States
 

Good Samaritan Med Ctr
Phoenix,  Arizona,  85006
United States
 

UCSF Hosp
San Francisco,  California,  941430654
United States
 

Harper Hosp
Detroit,  Michigan,  48201
United States
 

Mem Hosp Hollywood
Hollywood,  Florida,  33021
United States
 

Regional Oncology Ctr
Daytona Beach,  Florida,  32015
United States
 

Univ TX Galveston Med Branch
Galveston,  Texas,  77550
United States
 

ViRx Inc
San Francisco,  California,  94103
United States
 

George Washington Univ Med Ctr
Washington D.C.,  District of Columbia,  20037
United States
 

Baroness Erlanger Hosp
Chattanooga,  Tennessee,  37403
United States
 

Eisenhower Med Ctr
Rancho Mirage,  California,  92270
United States
 

DeKalb Gen Hosp
Decatur,  Georgia,  30033
United States
 

Los Angeles County - USC Med Ctr
Los Angeles,  California,  90033
United States
 

Atlanta Hosp
Riverdale,  Georgia,  30274
United States
 

Henderson Gen Hosp
Hamilton,  Ontario, 
Canada
 

Gwinnett Med Ctr
Lawrenceville,  Georgia,  30245
United States
 

McGuire Virginia Med Ctr
Richmond,  Virginia,  23249
United States
 

St Petersburg Med Clinics
St. Petersburg,  Florida,  33705
United States
 

Arkansas Children's Hosp
Little Rock,  Arkansas,  72202
United States
 


Additional Information:
Study ID Numbers:
  012B;  056-150
Study Start Date: 
Record last reviewed: February 1990
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002304

Other Hiv Infections Studies:
1. A Study of Fluconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems

2. Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis.

3. A Randomized, Prospective, Double-Blind Study Comparing Fluconazole With Placebo for Primary and Secondary Prophylaxis of Mucosal Candidiasis in HIV-Infected Women

4. A Study of the Side Effects of L-743,872 in Men with Candidal Esophagitis

5. A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems

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A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems

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