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A Collaborative Double-Blind Placebo-Controlled Trial of Intravenous Ribavirin As a Treatment for Presumed Hantavirus Pulmonary Syndrome



A Collaborative Double-Blind Placebo-Controlled Trial of Intravenous Ribavirin As a Treatment for Presumed Hantavirus Pulmonary Syndrome

For Condition: Hantavirus Pulmonary Syndrome
Status: No longer recruiting
Sponsor(s): National Institute of Allergy and Infectious Diseases (NIAID) ,
Synopsis: The purpose is to test the safety and effectiveness of intravenous ribavirin therapy in persons with suspected and subsequently proven hantavirus infection. The hantavirus is spread through the air into the lungs when dry rodent feces are moved or disturbed. It is characterized by fever and bleeding.
Details: Patients are randomized to receive either ribavirin or a placebo for 7 days. At the completion of therapy, patients will be seen on follow-up visits on days 14, 28, and 84.
Eligibility:
Study Type:
  Interventional, Treatment, Double-Blind
Minimum Age/Maximum Age: 12 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: You may be eligible for this study if you: - Are 12 years of age or older. - Are not pregnant. - Agree to practice sexual abstinence or use accepted barrier methods of birth control/contraception. - Are not breast-feeding. - Have a positive blood test for hantavirus. - Have symptoms suggestive of hantavirus illness. Exclusion Criteria: You will not be eligible for this study if you: - Have severe low blood count (anemia). - Have a diagnosis of other respiratory viruses (influenza, RSV, etc.). - Have group A Streptococcus with symptoms of streptococcal pharyngitis, a positive culture from a normally sterile site, or symptoms of bacterial pneumonia. - Are HIV positive. - Have cancer. - Have had any period of irregular heartbeat. - Have had chemotherapy or other drugs that suppress the immune system within 30 days. - Have taken by mouth or injection any antiviral drug (other than acyclovir, famciclovir, amantadine or rimantadine.) - Have taken by mouth or injection corticosteroids equivalent to approximately 0.5 mg/kg prednisone. - Have taken any experimental drug within 30 days prior to enrollment.
Total Enrollment: 130

Location and Contact Information:

NIAID/DMID/CASG Central Unit
Birmingham,  Alabama,  35294
United States
 


Additional Information:
Study ID Numbers:
  95-066; 
Study Start Date: 
Record last reviewed: March 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001123

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1. A Collaborative Double-Blind Placebo-Controlled Trial of Intravenous Ribavirin As a Treatment for Presumed Hantavirus Pulmonary Syndrome

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